Streptococcal C5a peptidase (SCP), a recently discovered virulence factor of Streptococcus pyogenes, specifically cleaves the human serum chemotaxin C5a near its carboxyl terminus, destroying its ability to serve as a chemoattractant. We previously localized the SCP gene, scpA, to the 5.8-kb insert of the recombinant plasmid pTT1. Here we present the complete nucleotide sequence of scpA and its...

The application of solid polymer electrolytes (SPEs) is severely impeded by the insufficient ionic conductivity and low Li+ transference numbers (tLi+). Here, we report an iodine-driven strategy to address both two long-standing issues SPEs simultaneously. Electronegative iodine-containing groups introduced on chains effectively attract ions, facilitate transport, promote dissociation Li salts....

Abstract Study question Can single-cell transcriptomics and proteomics contribute to a better understanding uterine of leiomyoma tumorigenesis? Summary answer We demonstrate the significant involvement MAPK, PI3K-Akt, proteoglycan pathways in smooth muscle, endothelial perivascular cells tumorigenesis. What is known already Uterine leiomyomas (LM), also as fibroids, are benign tumors uterus tha...

New approach of breast cancer therapy is developed toward combination therapy with agent that have a specific molecular target. Our previous study showed that Citrus aurantifolia lime peels ethanolic extract (CPE) increased the sensitivity of MCF-7 cells againts doxorubicin. This study aims to observe the mechanism of combination CPE and doxorubicin in cell cycle modulation and apoptosis on MCF...

New approach of breast cancer therapy is developed toward combination therapy with agent that have a specific molecular target. Our previous study showed that Citrus aurantifolia lime peels ethanolic extract (CPE) increased the sensitivity of MCF-7 cells againts doxorubicin. This study aims to observe the mechanism of combination CPE and doxorubicin in cell cycle modulation and apoptosis on MCF...

Aggregation of polyoxometalates (POM) is largely responsible for the reduced performance POM-based energy-storage systems. To address this challenge, here, precise confinement single Keggin-type POM molecule in a porous carbon (PC) unimodal super-micropore (micro-PC) realized. Such single-molecule enables sufficient activity center exposure and maximum electron-transfer from micro-PC to POM, wh...

Several intracellular pathogens have developed diverse strategies to avoid targeting to lysosomes. However, they universally recruit lysosome-associated membrane protein 1 (LAMP1); the mechanism of LAMP1 recruitment remains unclear. Here, we report that a Salmonella effector protein, SipC, specifically binds with host Syntaxin6 through its C terminus and thereby recruits Syntaxin6 and other acc...

INTRODUCTION Muscle weakness determines functional impairment in spastic cerebral palsy (SCP). Measurement of specific force (SF) allows for strength comparison with unimpaired populations (controls) accounting for neural (activation and coactivation), architectural (fascicle length and pennation angle), and structural differences (moment arm length). METHODS Medial gastrocnemius (MG) SF (and...

background: the rh antigens are expressed as parts of a protein complex in the rbc membrane. this complex is a tetramer, consisting of two molecules of rhag and two molecules of rh proteins. to express rhd in rbc membrane, expression of rhag is essential. this co-expression only occurs in the erythroid lineage. k562 cell line has an erythroid lineage. materials and methods: cord blood was used ...