ickle cell disease (SCD) is an inherited red blood cell disorder, haracterized by chronic hemolysis, vaso-occlusive complicaions and progressive multi-organ damage, with major impact n the patients’ life expectancy and quality of life.1,2 The incience of SCD is estimated as more than 300 000 new cases orldwide per year.3 The estimated incidence of SCD in Brazil s 3500 new cases per year.4 SCD p...

Approximately 100,000 Americans have sickle cell disease (SCD), a group of recessively inherited red blood cell disorders characterized by abnormal hemoglobin, called hemoglobin S or sickle hemoglobin, in the red blood cells. Persons with hemoglobin SS or hemoglobin Sß0 thalassemia, also known as sickle cell anemia (SCA), have the most severe form of SCD. Hemoglobin SC disease and hemoglobin Sß...

Sudden cardiac death (SCD) from cardiac arrest is a major international public health problem accounting for an estimated 15%-20% of all deaths. Although resuscitation rates are generally improving throughout the world, the majority of individuals who experience a sudden cardiac arrest will not survive. SCD most often develops in older adults with acquired structural heart disease, but it also ...

Sickle cell disease (SCD) is a major global health concern. Patients with SCD experience disproportionately greater morbidity and mortality in response to influenza infection than do others. Viral infection is one contributing factor for the development of Acute Chest Syndrome (ACS), a major cause of morbidity and mortality in SCD patients. We determined whether the heightened sensitivity to in...

BACKGROUND Sudden cardiac death (SCD) is an important cause of mortality even among apparently healthy populations. However, our ability to identify those at risk for SCD in the general population is poor, and more specific markers are needed. METHODS AND RESULTS To compare and contrast the relative importance of C-reactive protein (CRP), homocysteine, and lipids as long-term predictors of SC...

BACKGROUND Sickle cell disease (SCD) is a fatal monogenic disorder with no effective cure and thus high rates of morbidity and sequelae. Efforts toward discovery of disease modifying drugs and curative strategies can be augmented by leveraging the plethora of information contained in available biomedical literature. To facilitate research in this direction we have developed a resource, Dragon E...

BACKGROUND Asymptomatic individuals account for the majority of sudden cardiac deaths (SCDs). Development of effective, low-cost, and noninvasive SCD risk stratification tools is necessary. METHODS AND RESULTS Participants from the Atherosclerosis Risk in Communities study and Cardiovascular Health Study (n=20 177; age, 59.3±10.1 years; age range, 44-100 years; 56% female; 77% white) were fol...

BACKGROUND Sudden cardiac death (SCD) is a leading cause of death in the United States and often occurs without previous cardiac symptoms. Lifetime risk for SCD and the influence of established risk factors on lifetime risks for SCD have not been estimated previously. METHODS AND RESULTS We followed Framingham Heart Study participants who were free of cardiovascular disease before their earli...

BACKGROUND Few prospective studies have examined quantitative cigarette consumption and smoking cessation on sudden cardiac death (SCD) risk with long-term follow-up. METHODS AND RESULTS We prospectively examined the association between cigarette smoking and smoking cessation on the risk of SCD among 101 018 women participating in the Nurses' Health Study without known coronary heart disease,...

A disease is considered neglected when it not given due priority in health policies despite the social relevance of that disease, either terms number individuals affected by or its morbidity mortality. Although causes are structural, neglect does occur a vacuum. In this paper, we explore how sickle cell (SCD) constructed and Brazil, based on insights from our long-term participatory qualitative...