Sepsis caused by gram positive and gram negative bacteria is the leading cause of death in noncoronary ICUs and the tenth leading cause of death in the United States. We have developed a microfluidic sample preparation platform for rapid on-chip detection of infectious organisms for point-of-care diagnostics. The microfluidic chips are made of a robust thermoplastic and can be easily multiplexe...

Pyrrole-imidazole polyamides are DNA-binding molecules that are programmable for a large repertoire of DNA sequences. Typical syntheses of this class of heterocyclic oligomers rely on solid-phase methods. Solid-phase methodologies offer rapid assembly on a micromole scale sufficient for biophysical characterizations and cell culture studies. In order to produce gram-scale quantities necessary f...

In this paper, we introduce a novel approach for modeling n-grams in a latent space learned from supervised signals. The proposed procedure uses only unigram features to model short phrases (n-grams) in the latent space. The phrases are then combined to form document-level latent representation for a given text, where position of an n-gram in the document is used to compute corresponding combin...

Top-k approximate querying on string collections is an important data analysis tool for many applications, and it has been exhaustively studied. However, the scale of the problem has increased dramatically because of the prevalence of the Web. In this paper, we aim to explore the efficient top-k similar string matching problem. Several efficient strategies are introduced, such as length aware a...

In this paper, we report on the development of a large-scale Finnish Internet parsebank, currently consisting of 1.5 billion tokens in 116 million sentences. The data is fully morphologically and syntactically analyzed and it has been used to extract flat and syntactic n-gram collections, as well as verb-argument and nounargument n-grams. Additionally, distributional vector space representation...

discussion: the present case demonstrates that the uropathogenic e. hermanii clone can cause destruction of the kidneys. during asymptomatic bacteriuria or cystitis, the bacteria remain in the urinary tract. even when pyelonephritis develops, inflammatory response of the host is still restricted to the urinary tract. these signs mean that uropathogenic e. hermanii may be not very virulent. intr...

background :   imipenem-resistant gram negative bacteria, resulting from metallo-beta-lactamase (mbls)-producing strains have been reported to be among the important causes of nosocomial infections and of serious therapeutic problem worldwide. because of their broad range, potent carbapenemase activity and resistance to inhibitors, these enzymes can confer resistance to almost all beta-lactams....

We present a scalable and accurate method for classifying program traces to detect system intrusion attempts. By employing inter-element dependency models to overcome the independence violation problem inherent in the Naïve Bayes learners, our method yields intrusion detectors with better accuracy. For efficient counting of n-gram features without losing accuracy, we use a k-truncated generaliz...

In present paper, we propose a new method of n-gram analysis using ZBDDs (Zero-suppressed BDDs). ZBDDs are known as a compact representation of combinatorial item sets. Here, we newly apply the ZBDD-based techniques for efficiently handling sets of sequences. Using the algebraic operations defined over ZBDDs, such as union, intersection, difference, etc., we can execute various processings and/...

bacterial utilize a multitude of methods to secretion of specific substrate across phospholipid membranes. these bacterial strategies can play many roles in promoting bacterial process, from enhancing pathogenesis to bacterial response to environmental condition. the secretion in bacterial species transfer and release performance substance such as proteins, enzymes and metabolites to environmen...