Chronic kidney disease (CKD) accelerates muscle protein degradation by stimulating the ubiquitin proteasome system through activation of the E3 ligases, Atrogin-1/MAFbx and MuRF-1. Forkhead transcription factors (FoxOs) can control the expression of these E3 ligases, but the contribution of individual FoxOs to muscle wasting is unclear. To study this we created mice with a muscle-specific FoxO1...

Synopsis–Women’s right to safe and legal abortion is under threat worldwide. News of the French abortion pill, RU 486, which is touted by its promoters as safe, quick, and easy with the control in women’s hands, seems like the much awaited panacea to change the abortion debate. However, in this paper we dispute that chemical abortion is the answer to women’s demand for hassle-free and safe abor...

Long noncoding RNAs (lncRNAs) have been wildly demonstrated to participate in the osteosarcoma tumorigenesis. ZFAS1 is a novel identified lncRNA, however, its role in osteosarcoma is still unclear. In present study, we utilize lncRNA microarray assay to screen the lncRNA expression profile in osteosarcoma tissue, and investigate the regulatory function of ZFAS1 in osteosarcoma. LncRNA microarra...

The effects of chronic administration of methylprednisolone (MP) were studied on the ontogeny of the renal type II Na-Pi transporter (NaPi-2). Immunoblot analysis showed that MP did not alter the expression of NaPi-2 protein levels in suckling and weanling rats; however, there was an ∼50% decrease in adolescent and adult rats. There was no change in Na-dependent Pi uptake in brush-border membra...

BACKGROUND With its high morbidity and mortality, acute myocardial infarction (AMI) places a major burden on society and on individual patients. Correct, early correct diagnosis is crucial to the management of AMI. METHODS In this study, the expression of circulating miR-486 and miR-150 was investigated in AMI patients and the two miRNAs were evaluated as potential biomarkers for AMI. Plasma ...

[This corrects the article on p. 486 in vol. 7, PMID: 28018223.].