Soft tissue sarcomas are a heterogeneous group of malignant neoplasms of mesenchymal origin. They account for approximately 1% of all cancer diagnoses and 7% of pediatric malignancies (1,2). Just over half of these patients eventually succumb as a result of the disease. Soft tissue sarcomas typically present as asymptomatic large masses within the retroperitoneum or the proximal lower limbs but...

Cell death can occur through different mechanisms, defined by their nature and physiological implications. Correct assessment of cell death is crucial for cancer therapy success. Sarcomas are a large and diverse group of neoplasias from mesenchymal origin. Among cell death types, apoptosis is by far the most studied in sarcomas. Albeit very promising in other fields, regulated necrosis and othe...

Uterine sarcomas are rare and, consequently, data supporting the use of adjuvant radiotherapy in uterine sarcomas consist of few randomised studies and multiple single-institution retrospective reports. It is becoming increasingly clear that each histologic subtype of uterine sarcoma is a distinct entity for which tailored treatment recommendations are needed. In this review, we analysed the ef...

The mutagenic properties of ionizing radiation are well known, but the presence of specific mutations in human radiation-induced tumours is not established. We have studied a series of 36 secondary sarcomas arising in the irradiation field of a primary tumour following radiotherapy. The allelic status and the presence of mutations of the TP53 gene were investigated. The mutation pattern was com...

Soft tissue sarcomas arising in the head and neck are rare among adults. They account for approximately 10% of all soft tissue sarcomas and approximately 1% of head and neck tumors. Leiomyosarcomas are among the unusual soft tissue sarcomas in the head and neck which account about 0.2% of the cases in the reported series(1). Leiomyosarcoma of the tongue is a very rare tumor. Reviewing of litera...

Soft tissue sarcomas arising in the head and neck are rare among adults. They account for approximately 10% of all soft tissue sarcomas and approximately 1% of head and neck tumors. Leiomyosarcomas are among the unusual soft tissue sarcomas in the head and neck which account about 0.2% of the cases in the reported series(1). Leiomyosarcoma of the tongue is a very rare tumor. Reviewing of litera...

Pre-operative diagnosis of fortuitous rare tumors require careful clinico-pathological review; representing challenges to diagnose sarcomas in clinical practice especially developing countries. Studies are needed that signifies their clear representation.

Soft tissue sarcomas are rare mesenchymal tumors. Amongst others, primitive neuroectodermal tumors (PNET) of the kidney and synovial sarcoma of the kidney belong to the group of soft tissue sarcomas. Synovial sarcomas can occur almost anywhere in the body, most frequently, however, in the lower (62%) or upper extremities (21%). Metastases occur in 50-70% of cases, and thus the prognosis is poor...

Breast sarcomas are rare tumors with an incidence of <1% of all breast malignancy [1]. Primary breast sarcomais defined as malignancy originating from mesenchymal tissue of the breast and does not include those arising from skin, muscle, and adjacent bones. They are similar to soft tissue sarcomas elsewhere in the body. Primary fibrosarcoma of the breast is a very rare tumor described in litera...

Purpose/Results. Ionizing radiation is carcinogenic and the induction of a second malignancy is a serious potential long-term complication of radiotherapy. The incidence of radiation-induced sarcomas was evaluated from many large epidemiological surveys of long-term cancer survivors reported in the literature over the past 30 years and only one case was found for every 1000 patients irradiated....