To identify the potential impact of novel therapeutic approaches, we studied the early predictive factors of survival at the onset of acute respiratory distress syndrome (ARDS) in a 24-bed medical ICU of an academic tertiary care hospital. Over a 48-mo period, a total of 3,511 adult patients were admitted and 259 mechanically ventilated patients met ARDS criteria, as defined by American-Europea...

The SAPS algorithm is a Dynamic Local Search (DLS) algorithm conceptually closely related to the Exponentiated Sub-Gradient (ESG) algorithm developed by Schuurmans, Southey and Holte [3]. When introducing SAPS, our major contributions were a reduction in the algorithmic complexity as compared to the ESG algorithm and a new perspective on how the two algorithms were behaving. The SAPS algorithm ...

Critically ill cirrhotic patients with acute kidney injury (AKI) are associated with high mortality rates. The aims of this study were to develop a specific prognostic score for critically ill cirrhotic patients with AKI, the acute kidney injury - Chronic Liver Failure - Sequential Organ Failure- Assessment score (AKI-CLIF-SOFA) score. This study focused on 527 cirrhotic patients with AKI admit...

BACKGROUND & OBJECTIVES Postmenopausal women constitute an ideal model for studying the extent of hypothalamo-pituitary gonadal (HPG) axis suppression in critical illness as the gonadotropins are normally high and non-cyclical in them. The objective was to assess the impact of acute severe illness in postmenopausal women on the HPG axis and the activities of the hypothalamo-pituitary-adrenal (H...

2000;67:603–6. 13. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992;101:1644–55. 14. Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Ph...

INTRODUCTION Patients with haematological malignancy admitted to intensive care have a high mortality. Adverse prognostic factors include the number of organ failures, invasive mechanical ventilation and previous bone marrow transplantation. Severity-of-illness scores may underestimate the mortality of critically ill patients with haematological malignancy. This study investigates the relations...

OBJECTIVE Identify prognostic factors related to mortality and non-recovery of renal function. METHODS A prospective single-center study was conducted at the intensive care medicine department of a university hospital between 2012 and 2015. Patients with acute kidney injury receiving continuous renal replacement therapy were included in the study. Clinical and analytical parameters were colle...

System Performance Variation in SAPS performance is one of the primary concerns that inspired this research. Figures 3.1, 3.2, and 3.3 show the performance of the PMAC system as it relates to pH adjustment, total iron removal, and alkalinity generation respectively. The PMAC system demonstrated a consistent ability to treat severely contaminated AMD when maintained properly. It has raised the p...