نتایج جستجو برای: saos 2

تعداد نتایج: 2525365  

Journal: :The Journal of clinical endocrinology and metabolism 2002
Ayesha Siddiqi Marie P Parsons John L Lewis John P Monson Graham R Williams Jacky M Burrin

Thyroid hormones influence both bone formation and bone resorption. In vitro studies demonstrate direct effects of thyroid hormones on cells of the osteoblast lineage. Transcriptional regulation by thyroid hormones is mediated by ligand-dependent transcription factors called TRs. The three main T(3)-binding TR isoforms are TRalpha1, TRbeta1, and TRbeta2. TRs have been identified in cells of the...

2010
Mark R. Sommerfeld Günter Müller Georg Tschank Gerhard Seipke Paul Habermann Roland Kurrle Norbert Tennagels

BACKGROUND Insulin glargine (Lantus) is a long-acting basal insulin analog that demonstrates effective day-long glycemic control and a lower incidence of hypoglycemia than NPH insulin. After subcutaneous injection insulin glargine is partly converted into the two main metabolites M1 ([Gly(A21)]insulin) and M2 ([Gly(A21),des-Thr(B30)]insulin). The aim of this study was to characterize the glargi...

Journal: :Molecular pharmacology 2003
Dong Xu Deitmar Falke R L Juliano

Selective killing of tumor cells is an important goal for cancer therapeutics. The tumor suppressor transcription factor p53 is absent or mutated in more than 50% of human tumors. Thus, determining approaches that use p53 status to regulate therapy may be an important strategy for attaining cancer selectivity. We have shown previously that a designed transcriptional repressor, K2-5F, strongly a...

2009
Nurdan Özkucur Thomas K. Monsees Srikanth Perike Hoa Quynh Do Richard H. W. Funk

BACKGROUND Investigation of the mechanisms of guided cell migration can contribute to our understanding of many crucial biological processes, such as development and regeneration. Endogenous and exogenous direct current electric fields (dcEF) are known to induce directional cell migration, however the initial cellular responses to electrical stimulation are poorly understood. Ion fluxes, beside...

2013
Takao Fukuda Terukazu Sanui Kyosuke Toyoda Urara Tanaka Takaharu Taketomi Takeshi Uchiumi Fusanori Nishimura

Emdogain (enamel matrix derivative, EMD) is well recognized in periodontology. It is used in periodontal surgery to regenerate cementum, periodontal ligament, and alveolar bone. However, the precise molecular mechanisms underlying periodontal regeneration are still unclear. In this study, we investigated the proteins bound to amelogenin, which are suggested to play a pivotal role in promoting p...

Journal: :African Journal of Traditional, Complementary and Alternative Medicines 2013

2018
Maria Eugenia Marques da Costa Estelle Daudigeos-Dubus Anne Gomez-Brouchet Olivia Bawa Valerie Rouffiac Massimo Serra Katia Scotlandi Conceição Santos Birgit Geoerger Nathalie Gaspar

Osteosarcoma is one of the most common primary bone tumors in childhood and adolescence. Metastases occurrence at diagnosis or during disease evolution is the main therapeutic challenge. New drug evaluation to improve patient survival requires the development of various preclinical models mimicking at best the complexity of the disease and its metastatic potential. We describe here the developm...

Journal: :Cancer research 1983
H Diddens D Niethammer R C Jackson

Methotrexate (MTX)-resistant sublines of malignant human cells were selected in vitro by stepwise increase in drug concentration in the medium. By this procedure a subline of Burkitt's lymphoma cells (RAJI) was made 290-fold resistant (RAJI/MTX-R), T-cell leukemia cells (CCRF-CEM) were obtained 210-fold resistant (CEM/MTX-R), and 3 MTX-resistant human osteosarcoma lines were selected: TE-85/MTX...

Journal: :International journal of oncology 2013
Hyeon Jun Kim Seung Gee Lee Yoon-Jae Kim Ji-Eun Park Kyu Yeol Lee Young Hyun Yoo Jong-Min Kim

Osteosarcoma (OS) is the most common primary malignant bone cancer in children and adolescents. Although paclitaxel (PCX) has been considered one of the most important cancer chemotherapeutic drugs, the current protocols for OS treatment do not incorporate this agent. Therefore, the purpose of this study was to evaluate the induction of cell death in OS cells after exposure to PCX, to identify ...

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