MOTIVATION For genome-scale RNAi research, it is critical to investigate sample size required for the achievement of reasonably low false negative rate (FNR) and false positive rate. RESULTS The analysis in this article reveals that current design of sample size contributes to the occurrence of low signal-to-noise ratio in genome-scale RNAi projects. The analysis suggests that (i) an arrangem...

The importance of assessing fidelity has been emphasized recently with increasingly sophisticated definitions, assessment procedures, and integration of fidelity data into analyses of outcomes. Fidelity is often measured through observation and coding of instructional sessions either live or by video. However, little guidance has been provided about how to determine the number of observations n...

determination of an optimum sample size for the evaluation of sugar beet quality is of vital importance. a desirable sugar beet sample could represent confidently the sugar content and quality of delivered beets to the sugar factories. this experiment was carried out at research station of kamalshahr, karadj, iran. the experimental field was about 2000 m2 with the distance between rows and plan...

In the planning and design of new clinical trials, calculation of the required sample size and power is a critical part of the process. Power calculations are usually based on quantities estimated from analysis of historical data and are therefore subject to uncertainty. In many cases this is addressed by sensitivity analysis, but simple sensitivity analysis gives an incomplete picture of the u...

In this paper I address the question-how large is a phylogenetic sample? I propose a definition of a phylogenetic effective sample size for Brownian motion and Ornstein-Uhlenbeck processes-the regression effective sample size. I discuss how mutual information can be used to define an effective sample size in the non-normal process case and compare these two definitions to an already present con...