Previously, we presented in vivo evidence for a physiological significance of cAMP-regulated CFTR Cl(-) channels in Ca(2+)-activated Cl(-) reabsorption in the ductal system of the rat submandibular gland. Here, we address the mechanism by which basal CFTR activation contributes to the transepithelial Cl(-) movement evoked by muscarinic stimulation. The Cl(-) concentration ([Cl(-)]) was increase...

OBJECTIVES Radioiodine (RI) therapy is known to subject cellular components of salivary glands (SG) to oxidative stress leading to SG dysfunction. However, the protective effects of antioxidants on RI-induced SG damage have not been well investigated. The authors investigated the morphometric and functional effects of epigallocatechin-3-gallate (EGCG) administered prior to RI therapy and compar...

To investigate functions of the homeodomain-containing transcription factor Nkx3.1 a null mutation was generated by targeted gene disruption introducing the bacterial LacZ gene as reporter into the locus. In addition to defects in duct morphogenesis of the prostate and bulbourethral gland displaying progressive epithelial hyperplasia and reduced ductal branching (Bhatia-Gaur, R., Donjacour, A.A...

Aim: This paper reports a case of mucocele in the left side lower lip treated by conventional surgical excision lesion.Background: Mucoceles are most frequently occurring benign salivary gland lesion.The common site occurrence mucocelein oral cavity is lip. Extravasation type lesion because extravasation mucus secretion into fibrous connective tissue that result from an alterationof minor gland...

Variants of the prototype Alphavirus, Sindbis (SINV), were used in per os infections of adult female mosquitoes to investigate arbovirus interaction with the salivary gland (SG). Infection of Aedine mosquitoes with AR339, a heparan sulfate proteoglycan (HSPG)-dependent variant, resulted in gross pathology in the SG lateral lobes while infection with TR339, a HSPG-independent variant, resulted i...

OBJECTIVES/HYPOTHESIS In sialendoscopy, stents are often used to keep the salivary duct open after surgery. These stents need to be removed. Recently, our group developed a new starch-based shape-memory material that is a widespread degradable polymer. Such a device could be manufactured into a deployable resorbable stent to keep the salivary duct open before in situ degradation. An experimenta...

a total of 1500 infected liver with f. hepatica and f. gigantica from slaughtered cattle in different parts of iran were studied. grossly the livers were usually irregular in shape, with prominent bile ducts on the visceral surface as grayish-white, firm-branching streaks. the atrophy of the left lobe due to fibrosis and ischemia were noticed. on the cut surface the main bile ducts wall consist...

Purpose: To evaluate nuclear NF-kB translocation in minor salivary glands (mSG) of human primary Sjögren Syndrome (pSS). Methods: Lip biopsies’ mSG were done in 24 female patients with pSS from the Rheumatology Service of Rivadavia Hospital. Glands were stained with H&E and immunostained for NF-kB. Specimens were classified according to the Chisholm and Masson score. Results: The biopsies (H&E ...