Sulphasalazine, one of the 5-amino-salicylates, is widely used for the treatment of inflammatory bowel diseases and arthritis. Among the reported adverse effects are blood dyscrasias and hepatic failure. Peripheral neuropathy has been reported as a rare adverse drug reaction to sulphasalazine. Most reported patients developed symptoms several weeks after onset of treatment. We describe a patien...

Numerous cases of Rheumatic fever have lately been reported in the various Medical Journals, successfullytreated by the Salicylates. I subjoin the notes of a recent case I have had in which a speedy recovery took place. Mrs. ?, set. 20. The disease set in with all the symptoms of a very severe attack of catarrh, accompanied with ulcerated sore-throat, and enlarged glands of the neck, a sensatio...

Exclusion diets may have a practical place in determining the precipitating dietary factors in certain clinical conditions. We present an exclusion diet which is based on the exclusion of food commonly known to cause food allergies, and the exclusion of food which contains salicylates, benzoates, tartrazine, yeast, and penicillin. This provided a basis for challenge with these additives and nat...

History.?The patient had been ill for about five days, complaining of pains all over, but in particular in her legs. She also had been vomiting and had suffered from some slight fainting attacks. Her doctor had been treating her with salicylates for the pains, which he naturally took to be rheumatic in origin, this opinion being apparently corroborated by a slight swelling of the ankles, which ...

Non-acetylated salicylates have been recommended for use as alternatives to nonsteroidal anti-inflammatory drugs (NSAIDs) in aspirin and/or tartrazine-sensitive patients. We experienced a case of an aspirin-sensitive asthmatic patient who developed a broncho-obstructive reaction after taking 100 mg of sodium salicylate. The result of this study suggests that sodium salicylate may cross-react wi...

Urticaria and angio-oedema are a symptom complex covering a wide range of clinical disorders. Specific types are now well described, and it appears that many cases of idiopathic chronic urticaria which make up the vast majority of patients referred for assessment are due to intolerance to natural salicylates, preservatives and colouring agents. There is, therefore, an urgent need for legislatio...