Ribosomal protein S19 (RPS19) is a 16-kDa protein found mainly as a component of the ribosomal 40 S subunit. Its mutations are responsible for Diamond Blackfan anemia, a congenital disease characterized by defective erythroid progenitor maturation. Dysregulation of RPS19 has therefore been implicated in this defective erythropoiesis, although the link between them is still unclear. Two not mutu...

Regeneration is a trait observed in various metazoans to differing extents. We are interested in how some species manage to regenerate complex structures and why this ability has been lost in other species. Among vertebrates, the salamanders have the most impressive regenerative abilities that includes appendage and spinal cord regeneration as well as regeneration of a number of organs such as ...

Abstract Many soil microorganisms’ i.e., bacteria and fungi produce secondary metabolites called antibiotics. These are used for the treatment of some bacterial, fungal protozoal diseases humans. There is a need isolation broad spectrum antibiotics from microorganisms due to emergence antibiotic resistance. In present study two producing Klebsiella pneumoniae Bacillus cereus were isolated pharm...

1 This study aimed to evaluate the use of Protein A-peroxidase (HRPO) in indirect ELISA 2 (iELISA) and IgG avidity assays for serological distinction between Brucella abortus S193 vaccinated and infected cows. Four groups were analyzed: (GI) 41 non-vaccinated seropositive 4 cows; (GII) 79 S19-vaccinated heifers analyzed at 3 months post-vaccination; (GIII) 105 S195 vaccinated cows analyzed afte...

We have performed 50 independent molecular dynamics (MD) simulations to determine the effect of pseudophosphorylation mutants on the structural dynamics of smooth muscle myosin (SMM) regulatory light chain (RLC). We previously showed that the N-terminal phosphorylation domain of RLC simultaneously populates two structural states in equilibrium, closed and open, and that phosphorylation at S19 i...

We describe the use of biologically active cDNA clones to investigate genetic determinants of a satellite RNA that modulates symptoms normally induced by its helper virus, cucumber mosaic virus (CMV). For this purpose, we have investigated a CMV satellite RNA (Y-satRNA) that induces bright yellow symptoms on tobacco and necrosis on tomato. To determine the pathogenicity-modulating domain of Y-s...