The main protease (Mpro) of severe acute respiratory syndrome coronavirus (SARS CoV) is a key enzyme for viral replication, and is thus an attractive target for anti-SARS CoV drug development. Mpro belongs to the family of 3C-like cysteine proteases. The basic design of peptidomimetic inhibitors involved a warhead that can form covalent modifications to the –SH group of the active site residue ...

Gadolinium oxide (Gd2O3), which can be used as a T1-weighted magnetic resonance imaging (MRI) contrast agent, has attracted intense attention in recent years. In this paper, ligand-free monoclinic Gd2O3 nanocrystals of 7.1 nm in diameter are synthesized by a simple and green approach, namely microsecond laser ablation of a gadolinium (Gd) target in deionized water. These nanocrystals obtain hig...

H/ACA small nucleolar RNPs (snoRNPs) that guide pseudouridylation reactions are comprised of one small nucleolar RNA (snoRNA) and four common proteins (Cbf5, Gar1, Nhp2 and Nop10). Unlike other H/ACA snoRNPs, snR30 is essential for the early processing reactions that lead to the production of 18S ribosomal RNA in the yeast Saccharomyces cerevisiae. To determine whether snR30 RNP contains specif...

1997;45:273-81. 11 Campbell C. Selling sex in the time of AIDS: the psycho-social context of condom use by southern African sex workers. Soc Sci Med 2000;50:479-94. 12 MacPhail C, Campbell C. “I think condoms are good but, aai, I hate those things”: condom use among adolescents and young people in a southern African township. Soc Sci Med 2001;52:1613-27. 13 Stockdale J. The self and media messa...

The diversity of the rhizosphere arbuscular mycorrhizal fungi (AMF) community is a crucial factor affecting root-soil interaction. They can absorb carbohydrates from host body and return nutrient elements soil to host. Using 15 Chinese fir ( Cunninghamia lanceolata Lamb. Hook.) clones, AMF richness, abundance structure in “Root system-Rhizosphere soil-Bulk soil” were obtained by Real-time quant...

Mutations in several ribosomal proteins (RPs) lead to Diamond-Blackfan anemia (DBA), a syndrome characterized by defective erythropoiesis, congenital anomalies, and increased frequency of cancer. RPS19 is the most frequently mutated RP in DBA. RPS19 deficiency impairs ribosomal biogenesis, but how this leads to DBA or cancer remains unknown. We have found that rps19 deficiency in ze-brafish res...