Background: Non-Hodgkin’s lymphoma (NHL) rarely occurs in the base of tongue. The aim of the study was to investigate the clinicopathological findings in patients with base-of-tongue NHL. Methods: The computerized files of 10 patients with primary NHL in the base of the tongue from 1997 to 2007 at a major tertiary medical center were reviewed. Results: There are three females and seven males ag...

Lymphoma is a blood tumor, with an incidence of 11 cases per 100,000 inhabitants being 25% Hodgkin lymphoma (HL) and 75% non-Hodgkin's lymphoma (NHL). Peripheral neurological involvement is very uncommon (1-5% of lymphomas) and the most are due to NHL. The mechanisms described in peripheral neurological involvement are extrinsic tumor compression, direct infiltration, chemoradiotherapy, infecti...

Although previously characterized as a subtype of diffuse large B-cell lymphoma, primary mediastinal lymphoma (PMBCL) is now recognized distinct NHL with unique clinical and biologic features, many which overlap classic Hodgkin lymphoma. PMBCL has peak incidence in the adolescent young adult (AYA) population and, unlike other subtypes NHL, higher among females. Recent studies into molecular bio...

INTRODUCTION The use of rituximab has led to significant improvements in the outcome of both aggressive and indolent Non-Hodgkin's lymphoma (NHL). It is the first targeted therapy to be developed for the treatment of lymphoma which has been widely adopted. AREAS COVERED This paper discusses the use of rituximab in NHL, mainly concentrating on diffuse large B cell lymphoma (DLBCL) and follicul...

Certain malignant B cells rely on B-cell receptor (BCR)-mediated survival signals. Spleen tyrosine kinase (Syk) initiates and amplifies the BCR signal. In in vivo analyses of B-cell lymphoma cell lines and primary tumors, Syk inhibition induces apoptosis. These data prompted a phase 1/2 clinical trial of fostamatinib disodium, the first clinically available oral Syk inhibitor, in patients with ...

AIMS AND OBJECTIVES In this present study we have evaluated the feasibility of sub-classification of non-Hodgkin's lymphoma (NHL) cases according to World Health Organization's (WHO) classification on fine needle aspiration cytology (FNAC) material along with flow cytometric immunotyping (FCI) as an adjunct. MATERIALS AND METHODS In this five years study, only cases suggested or confirmed as ...

BACKGROUND Autologous or allogeneic hematopoietic stem cell transplant (SCT) is often considered in patients with relapsed or refractory non-Hodgkin lymphoma (NHL) but there are limited data on the use of SCT for the treatment of NHL in the pediatric setting. PROCEDURE To evaluate the role of SCT for children with NHL, we reviewed 36 consecutive pediatric patients with NHL who underwent an al...

BACKGROUND/AIMS In Asia, the incidence of non-Hodgkin lymphoma (NHL) has increased in recent decades. Waldeyer's ring (WR) is the most common site of NHL involving the head and neck. In this study, the pathological distribution of WR-NHL and its clinical features were analyzed retrospectively. METHODS From January 2000 through December 2010, we analyzed the medical records of 328 patients fro...

Introduction. Lymphomas are malignant diseases of the lymphocyte lineage. There two basic types lymphoma: Hodgkin's lymphoma (HL), whose main characteristic is presence Reed-Sternberg cells, and non-Hodgkin's (NHL), which presents a heterogeneous group diseases, depending on growth rate course disease, they can be indolent (slow-growing) aggressive (fast-growing). Follicular (FL) most common fo...

OBJECTIVE Non-Hodgkin lymphoma (NHL) is one of the most frequent malignancies in Jordan. The aims of this study are: 1. To classify NHL cases in Jordan, using the new World Health Organization (WHO) classification system, 2. To identify the most common types of NHL in Jordan, and 3. To compare lymphoma types and patterns in Jordan with those in surrounding countries and the West. METHODS We s...