AIM To investigate the impact of IL28B and OAS gene polymorphisms on interferon treatment responses in children with chronic hepatitis B. METHODS We enrolled 52 children (between the ages of 4 and 18) with hepatitis B e antigen-negative chronic hepatitis B (CHB), who were treated with pegylated interferon alfa for 48 wk. Single nucleotide polymorphisms in the OAS1 (rs1131476), OAS2 (rs1293747...

BACKGROUND Sustained virological response (SVR) and virological relapse maintain pivotal roles in the management of chronic hepatitis C (CHC); however, there is little data regarding the long-term outcomes of patients with CHC in China. OBJECTIVES We aimed to investigate the predictive factors of therapeutic effect and viral relapse in patients who achieved end-of-treatment response (ETR). ...

Single-nucleotide polymorphisms (SNPs) around IL28B are associated with spontaneous hepatitis C virus (HCV) clearance of genotypes 1 and 3 in white and African-American populations. This study investigated whether the IL28B SNP (rs12979860) is associated with spontaneous clearance of HCV, principally genotype 4, in 162 Egyptians (80 with clearance). The protective C allele was more common in th...

Hepatitis C virus (HCV) is a serious global health issue. Nearly 20% of HCV patients spontaneously clear the virus. While some studies have shown an association spontaneous clearance (SC) with interleukin (IL) 28B single-nucleotide polymorphisms (SNPs), others did not show such relationship. Thus, purpose present study was to investigate IL28B (12979860 SNP) SC infection. Upon initial screening...

Goal. To evaluate the genetic profi le of patients with chronic hepatitis C (CHC) by CAT gene polymorphism in region-262G/A (rs1001179), GPX4 region-718C/T (rs713041), IL28B region C/T (rs12979860) and VEGFA region- 634G/C (rs2010963) to analyze association rate progression liver fi brosis polymorphic markers. Materials methods. We examined 36 CHC a rapidly progressive (up 10 years) 56 slowly c...

Prevention of chronic hepatitis C (CHC) and its complications is based on antiviral therapy early detection reliable molecular markers in persons under risk. We investigated whether the methylation status RASSF1A p16 genes, alone or combination with host viral factors, affects response to pegylated interferon/ribavirin (PEG-IFN/RBV). Methylation-specific polymerase chain reaction (MSP) was used...