Recent studies have established ciliary dysfunction as the underlying cause of a broad range of multi-organ phenotypes, known as 'ciliopathies'. Ciliopathy-associated proteins have a common site of action in the cilium, however, their overall importance for ciliary function differs, as implied by the extreme variability in ciliopathy phenotypes. The aim of this study was to gain more insight in...

knowledge of lidocaine and physiology of the human iris, we can only speculate on its mechanism of action and the differences between the subsets observed in our study. Dr. Sodhi has suggested several mechanisms based on a literature review. They are interesting proposals, but to what extent those mechanisms are responsible for the differing effect of lidocaine on pigmented irides, we cannot sa...