Tobacco smoking is one of the most serious health problems. Potentially lethal effects nicotine for adults can occur with as little 30 to 60 mg, although severe symptoms arise lower doses. Furthermore, route administration also influences toxicity. Cytisine popular medications in nicotinism treatment. Like nicotine, cytisine a plant alkaloid, signaling through nicotinic acetylcholine receptors....

MOTIVATION Drug-induced toxicity related proteins (DITRPs) are proteins that mediate adverse drug reactions (ADRs) or toxicities through their binding to drugs or reactive metabolites. Collection of these proteins facilitates better understanding of the molecular mechanisms of drug-induced toxicity and the rational drug discovery. Drug-induced toxicity related protein database (DITOP) is such a...

In addition to increasing the efficacy of various drugs, Nanoparticles reduce their side effects. In this study, different nanoparticle formulations of Doxorubicin anticancer drugs were prepared. The efficacy of the formulations produced in the cell culture medium was studied compared with the free drug. Reverse phase evaporation was used to form the liposome containing do...

Microplastics (MPs) represent small plastic particles with sizes between 1 μm and 5 mm, are insoluble in water, andclassified as primary (these originally produced sizes) or secondary (the result of the degradation plastic) types. MPs accumulate all ecosystems, including freshwater environments, where they subjected to processes. Due their ubiquitous nature, which have a vital importance human ...

Cardiac toxicity is a dose-limiting toxicity that may occur during cancer treatment or several years after therapy ends. Cardiac toxicity may be caused by chemotherapy, biotherapy, and radiation therapy and may result in cardiomyopathy, congestive heart failure, dysrhythmias, and myocardial ischemia. The risk for developing cardiac toxicity varies based on type of treatment, patient age, presen...

Titanium dioxide (TiO2) nanofibres are a novel fibrous nanomaterial with increasing applications in a variety of fields. While the biological effects of TiO2 nanoparticles have been extensively studied, the toxicological characterization of TiO2 nanofibres is far from being complete. In this study, we evaluated the toxicity of commercially available anatase TiO2 nanofibres using TiO2 nanopartic...