The cardiac ischemia-reperfusion (I/R) injury greatly influences the therapeutic effect and remains an urgent challenge in clinical therapy. Polypharmacology opens a new therapeutic opportunity to design drugs with a specific target for improving the efficacy. In this study, we first forecasted that Rosmarinic acid (RosA) could be used for the treatment of cardiovascular disease using text mini...

BACKGROUND The present study investigates the cardioprotective effects of Hibiscus rosa sinensis in myocardial ischemic reperfusion injury, particularly in terms of its antioxidant effects. METHODS The medicinal values of the flowers of Hibiscus rosa sinensis (Chinese rose) have been mentioned in ancient literature as useful in disorders of the heart. Dried pulverized flower of Hibiscus rosa ...

The genus Rosa Linnaeus, 1753 has important economic value in ornamental sector and many breeding activities are going on supported by molecular studies. However, the cytogenetic studies of rose species are scarce and mainly focused on chromosome counting and chromosome morphology-based karyotyping. Due to the small size of the chromosomes and a high frequency of polyploidy in the genus, karyot...

Three-dimensional (3D) integration with through-die vias offer improved electrical performance compared to edgeconnected wire bonds in stacked-die assemblies. Monolithic wafer-level 3D integration offers the potential for a high density of micron-sized through-die vias necessary for highest performance of integrated systems. In addition, such wafer-level technologies offer the potential of lowe...

5 Damascene Process 5 History of Copper Interconnects 6 Damascene Process Steps 6 State of the Art in ECD 6 Electrochemical Deposition (ECD) 8 Basic ECD 11 V-I Curves 12 Uniformity 14 Boundary Layer 14 Conductivity 15 Bath Chemistry and Plating Waveforms 16 Superfilling 17 Morphology 17 A Look to the Future c o n t e n t s Interconnects in integrated circuits distribute clock and other signals ...

Precis coenia exhibits a seasonal color polyphenism. Animals reared under long-day conditions develop a pale tan pigmentation on their ventral hind wing (the linea form), whereas animals reared under short-day conditions develop a dark reddish-brown pigmentation (the rosa form). This developmental switch is mediated by a shift in the timing of ecdysteroid secretion at the outset of adult develo...

Paolo Ravanini, Eili Huhtamo, Essi Hasu, Felicita Rosa, Stefano Costantino, Maria G. Crobu, Valentina Ilaria, Anna M. Nicosia, Pietro L. Garavelli, and Olli Vapalahti Author affi liations: Azienda OspedalieroUniversitaria Maggiore della Carità, Novara, Italy (P. Ravanini, F. Rosa, S. Costantino, M.G. Crobu, V. Ilaria, A.M. Nicosia, P.L. Garavelli); and University of Helsinki, Helsinki, Finland ...

Island loggerhead shrikes (Lanius ludovicianus anthonyi) are an endemic, genetically distinct subspecies of loggerhead shrike on California’s Santa Rosa, Santa Cruz, and Santa Catalina Islands (USA). This subspecies is listed as a Species of Special Concern by the California Department of Fish and Game and has been petitioned for federal listing under the Endangered Species Act. The combination...

Nitric oxide (NO) has been known as a gaseous chemical mediator, which modulates several physiological functions. Spatial and temporal control of NO release facilitates further study and medical application of NO. Herein, we report design and synthesis of a novel NO donor, NO-Rosa. NO-Rosa has a rosamine moiety, which absorbs yellowish green light. Upon irradiation with yellowish green light (5...