BACKGROUND An exaggerated morning surge in blood pressure (BP) closely relates to target organ damage and cardiovascular risk, but whether the causative mechanism involves greater reactivity of the sympathetic nervous system (SNS) is unknown. We determined whether the response of the SNS to a cold pressor test predicted the BP morning surge. METHODS Ambulatory BP recordings were obtained from...

UNLABELLED Hybrid PET systems have spatially varying sensitivity profiles. These profiles are dependent on imaging parameters, namely, number of heads, head configuration, spacing between gantry stops, radius of rotation (RoR), and coincident head acceptance angle. METHODS Sensitivity profiles were calculated across a 500-mm field of view (FoV) for a representative set of existing and theoret...

OBJECTIVES This article describes the Web application framework for Electronic Health Records (EHRs) we have developed to reduce construction costs for EHR sytems. METHODS The openEHR project has developed clinical model driven architecture for future-proof interoperable EHR systems. This project provides the specifications to standardize clinical domain model implementations, upon which the ...

A genetic analysis of parasitic ability in the soybean cyst nematode Heterodera glycines was performed. To identify and characterize genes involved in parasitism, we developed three highly inbred H. glycines lines, OP20, OP25 and OP50, for use as parents for controlled crosses. Through these crosses, we have identified genes in the inbred parents that control reproduction of the nematode on hos...

Logic-based testers design tests from logical expressions that appear in software artifacts such as source code, design models, and requirements specifications. This paper presents three improvements to logic-based test design. First, in the context of mutation testing, we present fault hierarchies for the six relational operators. Applying the ROR mutation operator causes each relational opera...

This study was aimed to evaluate the possible alert signals of paraesthesia by local anaesthetics, focusing on those used in dentistry. A case/non-case study of spontaneous adverse events recorded in FAERS (FDA Adverse Event Reporting System) between 2004 and 2011 was performed. Cases were represented by the reports of reactions grouped under the term 'Paraesthesias and dysaesthesias' involving...

BACKGROUND AND OBJECTIVES Pediatric literacy promotion programs carried out in the primary care setting, such as Reach Out and Read (ROR), have been associated with improved language skills for preschool children. Primary care physicians have frequent contact with young families and may be well situated for a literacy promotion program for both children and adults. We examined whether introduci...

Perturbations in synaptic function could affect the normal behavior of an animal, making it important to understand the regulatory mechanisms of synaptic signaling. Previous work has shown that in Caenorhabditis elegans an immunoglobulin superfamily protein, RIG-3, functions in presynaptic neurons to maintain normal acetylcholine receptor levels at the neuromuscular junction (NMJ). In this stud...

Emerging infectious diseases (EIDs), the majority of which are zoonotic, represent a tremendous challenge for public health and biosurveillance infrastructure across the globe. Due to the complexity of zoonotic pathogens, it is essential that research and response to EIDs be a transdisciplinary effort. And while crisis and circumstance may be the initial catalyst for responding to an outbreak, ...

Retinoic acid receptor-related orphan receptor (ROR) agonists have been shown to regulate circadian rhythms in cultured cells and improve various disease outcomes animal models. Because expression of the core nucleotide excision repair protein XPA is governed by clock, we examined whether a natural synthetic ROR agonist (nobiletin SR1078, respectively) impact cellular responses UV radiation hum...