Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma of infancy and although therapy has improved over the years, mortality is still fairly high. The establishment of new treatments has been hampered by the limited knowledge of the molecular mechanisms driving development of RMS. One characteristic of cancer cells is aberrant DNA methylation, which could lead to silencing of tumor supp...

BACKGROUND The prognosis of rhabdomyosarcoma (RMS) in children and adolescents has improved since the introduction of multi-agent chemotherapy. However, outcome data of adults with RMS are scarce. This multicenter retrospective study investigated the effect of age on outcome of RMS. PATIENTS AND METHODS Data were collected from three Dutch University Medical Centers between 1977-2009. The eff...

R&D investment drives productivity growth. Therefore, its uctuations over the business cycle a ect long-run dynamics. I show that taking into account the size distribution of innovating rms generates new insights on this link. I write an endogenous growth model with heterogeneous rms assuming, in line with empirical evidence, that small rms have a relatively higher innovation capacity than larg...

Rhabdomyosarcoma (RMS) is an aggressive childhood soft tissue tumor, which exists in oncoprotein PAX-FOXO1 fusion positive and fusion negative subtypes, with the fusion-positive RMS being characterized by a more aggressive clinical behavior. Exosomes are small membranous vesicles secreted into body fluids by multiple cell types, including tumor cells, and have been implicated in metastatic prog...

dear editor:   we thank dr asadi amoli for her interest in our article. 1 dr asadi amoli pointed out that specific and sensitive rhabdomyosarcoma (rms) markers should be investigated in our case. 2 we agree with dr asadi amoli ’s opinion and are sorry that the results of pathology examination and myogenin (myf-4) staining studied in a local hospital were not provided in our case report.   an ex...

This report presents a novel orientation filter applicable to IMUs consisting of tri-axis gyroscopes and accelerometers, and MARG sensor arrays that also include tri-axis magnetometers. The MARG implementation incorporates magnetic distortion and gyroscope bias drift compensation. The filter uses a quaternion representation, allowing accelerometer and magnetometer data to be used in an analytic...

We examine the participation of public and private …rms in merger waves and their outcomes. We document that public …rms participate more in mergers than private …rms and are more cyclical in their acquisition decisions. Public …rms are also impacted more by macro factors including credit spreads and industry returns. Acquired plants gain more in productivity on average and the improvement is g...

This paper investigates equilibria in a labor market where heterogeneous …rms post wage/tenure contracts and risk-averse workers, both employed and unemployed, search for new job opportunities. Di¤erent …rms, even those with the same productivity, typically o¤er di¤erent contracts. Equilibrium …nds workers never quit from higher productivity …rms to lower productivity …rms, but turnover is ine¢...

Three algorithms for solving linearized systems of RF waveform design equations for calculating accelerated spatially-tailored excitations on parallel excitation MRI systems are presented. Their artifact levels, computational speed, and RF peak and root-mean-square (RMS) voltages are analyzed. An SVD-based inversion method is compared with conjugate gradient least squares (CGLS) and least squar...

Relatively little is known about the epidemiology and factors underlying susceptibility to childhood rhabdomyosarcoma (RMS). To better characterize genetic susceptibility to childhood RMS, we evaluated the role of family history of cancer using data from the largest case-control study of RMS and the Utah Population Database (UPDB). RMS cases (n = 322) were obtained from the Children's Oncology ...