The rat streptozotocin (STZ)-induced diabetes model is widely used to investigate the pathogenesis of diabetic nephropathy. However, overt nephropathy is inexplicably slow to develop in this model compared with renal mass reduction (RMR) models. To examine whether blood pressure (BP) differences correlated with the time course of glomerulosclerosis (GS), BP was measured continuously throughout ...

Molecular evolution is simultaneously paced by mutation rate, genetic drift, and natural selection. Life history traits also affect the speed of accumulation of nucleotide changes. For instance, small body size, rapid generation time, production of reactive oxygen species (ROS), and high resting metabolic rate (RMR) are suggested to be associated with faster rates of molecular evolution. Howeve...

PURPOSE To examine whether adaptations in physical activity energy expenditure (PAEE) and resting metabolic rate (RMR) during weight loss were associated with future weight regain in overweight/obese, older women. RESEARCH METHODS AND PROCEDURES Thirty-four overweight/obese (BMI = 25-40 kg x m(-2)), postmenopausal women underwent a 20-wk weight loss intervention of hypocaloric diet with (low-...

Bitter orange (Citrus aurantium) extract is widely used in dietary supplements for weight management and sports performance. Its primary protoalkaloid is p-synephrine. Most studies involving bitter orange extract and p-synephrine have used products with multiple ingredients. The current study assessed the thermogenic effects of p-synephrine alone and in conjunction with the flavonoids naringin ...

Global warming poses a threat to many ectothermic organisms because of the harmful effects that elevated temperatures can have on resting metabolic rate (RMR) and body size. This study evaluated the thermal sensitivity of Trinidadian guppies (Poecilia reticulata) by describing the effects of developmental temperature on mass, burst speed and RMR, and investigated whether these tropical fish can...

[1] New slope measurements from the Mars Orbiter Laser Altimeter (MOLA), in conjunction with the Rock Mass Rating system (RMR), permit inversions of slope height and angle from wallrock and interior deposits within Valles Marineris troughs for strength and lithology. Wallrock (50 < RMR < 65) is stronger than interior deposits (30 < RMR < 55). These values are consistent with layered igneous roc...

Superimposed on inherently high basal metabolic demands, the additional energetic requirements of reproduction can push female sea otters beyond physiological limits. Indeed, the resulting energy imbalance contributes to disproportionately high rates of mortality at the end of lactation in this species. To examine and quantify metabolic changes associated with reproduction, we measured the rest...

Resting metabolic rate (RMR) in humans shows pronounced individual variations, but the underlying molecular mechanism remains elusive. Cytochrome c oxidase (COX) plays a key role in control of metabolic rate, and recent studies of the subunit 4 isoform 2 (COX IV-2) indicate involvement in the cellular response to hypoxia and oxidative stress. We evaluated whether the COX subunit IV isoform comp...

PURPOSE Several studies of school-aged children with attention deficit hyperactivity disorder (ADHD) have found a higher prevalence of overweight/obesity compared with the general population. However, the scientific literature contains insufficient evidence to establish clear conclusions on pulmonary functions, resting metabolic rate (RMR), and body composition in children with ADHD. This study...

BACKGROUND The purpose of this investigation was to identify the onset of the thermic effect of feeding (TEF) after ingestion of a high carbohydrate (CHO) and a high protein (PRO) 1255 kJ (300 kcal) drink. METHODS Resting metabolic rate (RMR) and TEF were measured over 30-minute periods via indirect calorimetry using a ventilated hood technique. Eighteen subjects (7 men and 11 women) complete...