We report here the locations of curved DNA in the human erythropoietin receptor gene. A total of 13 DNA bend sites were mapped by circular permutation assays, appearing at an average interval of 651.2+/-214.6 (S.D.) in the 8-kb region. The bend centers in these 13 bend sites were confirmed by oligonucleotide-based assays where most of these centers had bend angles higher than that shown by (AAA...

The blood-brain barrier (BBB) is formed by brain endothelial cells. Many immortalized brain endothelial cell lines have been established; these have been used as in vitro BBB models. The aim of the present study was to assess the paracellular barrier properties of the immortalized mouse brain endothelial cell lines bEND.3, bEND.5 cells, and mouse brain endothelial cell 4 (MBEC4), and those of t...

Abstract Cenozoic surface uplift of Tibetan Plateau has driven the birth and reorganization large river systems in Asia. The development Yangtze River, closely linked to plateau uplift, important implications for regional tectonic‐geomorphology processes, but is still under debate. key scientific question whether Upper (upper Jinshajiang) once flowed southeast South China Sea. In this study, we...

When studying river hydrodynamics and water quality evolution laws on the basis of numerical simulation analysis, it is necessary to carry out topographic interpolation along bend direction measured section, as this can provide accurate reliable data for modeling. In paper, a two-step terrain method based sparse discrete sections proposed by comprehensively considering trends lack monitoring se...

Floodplain forests serve a critical function in the global carbon cycle because floodplains constitute an important carbon sink compared with other terrestrial ecosystems. Forests on dynamic floodplain landscapes, such as those created by river meandering processes, are characterized by uneven-aged trees and exhibit high spatial variability, reflecting the influence of interacting fluvial, hydr...

Identification of high potential risk and susceptible zones for natural hazards of geological origin is one of the most important applications of advanced remote sensing technology in tropical environments. Yearly, several landslides occur during heavy monsoon rainfall in Kelantan river basin, Peninsular Malaysia, which are obviously connected to geological structures and topographical features...

[1] We perform two-dimensional dynamic models of strike-slip faults with a change in strike (a bend) over multiple earthquake cycles to examine the long-term effects of nonplanar fault geometry. A viscoelastic model (a proxy for off-fault deformation and tectonic loading) is introduced for the interseismic process to avoid pathological stress buildup around the bend. A finite element method wit...

A numerical experiment is carried out to study the suitability of two-dimensional (2D) depth-averaged modeling for bend-flow simulation, in which the geometry of the studied channel is rectangular. Two commonly used 2D depth-averaged models for bend-flow simulation are considered in this study of which the bend-flow model includes the dispersion stress terms by incorporating the assumption of s...