BACKGROUND Whether to return individual research results from cancer genetics studies is widely debated, but little is known about how participants respond to results disclosure or about its time and cost burdens on investigators. METHODS We recontacted participants at one site of a multicenter genetic epidemiologic study regarding their CDKN2A gene test results and implications for melanoma ...

Fisher’s logarithmic series model (Fisher et al. (1943)) is a classical model in statistical ecology. In this paper we show that this model is a key model linking three models discussed in Takemura (1997), i.e., Poisson-gamma model (Bethlehem et al. (1990)), Dirichlet-multinomial model (Takemura (1997)), and Ewens model (Ewens (1990)). This connection opens up the possibility of applying existi...

BACKGROUND The apolipoprotein E (APOE) genotype provides information on the risk of Alzheimer's disease, but the genotyping of patients and their family members has been discouraged. We examined the effect of genotype disclosure in a prospective, randomized, controlled trial. METHODS We randomly assigned 162 asymptomatic adults who had a parent with Alzheimer's disease to receive the results ...

In the framework of disclosure control of a microdata set, an unique record is at risk of being identified. Even if a record is not unique in the microdata set, it may be considered risky if the frequency k of the cell, in which the record falls, is small. The notion of minimum unsafe combination introduced by Willenborg and de Waal (1996) is important in this respect. The purpose of this paper...

In this paper we investigate when public enforcement of insider trading regulations reduces the amount of insider trading. We model a game between a potentially self-interested regulator enforcing insider trading laws and a trader who may be trading on inside information. We show that equilibrium strategies exist where despite active enforcement all inside information is used. Furthermore, we f...