TRAIL (TNF-related apoptosis-inducing ligand) is a member of the tumor necrosis factor superfamily that can induce tumor selective death by up-regulating death receptor 4 (DR4) and DR5 expression. The study aimed to explore the role of RIP and c-FLIP genes in TRAIL induced liver cancer cell HepG2 and Hep3B apoptosis and related mechanism. RIP and c-FLIP silenced HepG2 and Hep3B cell model were ...

With use of the yeast two-hybrid system, the proteins RIP and FADD/MORT1 have been shown to interact with the "death domain" of the Fas receptor. Both of these proteins induce apoptosis in mammalian cells. Using receptor fusion constructs, we provide evidence that the self-association of the death domain of RIP by itself is sufficient to elicit apoptosis. However, both the death domain and the ...

In this paper, Swing-up and Stabilization of the Rotary inverted pendulum (RIP) is done through the fuzzy controller.The attraction of this paper is achieving the above stated aim through lesser number of rules. RIP is highly unstable and nonlinear in nature, so stabilization of the RIP is itself a challenging task. Swing-up mechanism in RIP is a type of unstable mechanism which is done effecti...

Purpose: This study was initiated to evaluate incidence, grade and dosimetric correlation of Clinical Radiation Induced Pneumonitis (RIP) (≥ grade 2) in lung cancer patients undergoing radical radiotherapy. Methods and Materials: From August, 2012 to November, 2013, 85 lung cancer patients received curative 3D CRT. On follow up 14 patients developed symptomatic pneumonitis (≥ Grade 2 as per RTO...

Regulated intramembrane proteolysis (RIP) is a critical mechanism for intercellular communication and regulates the function of membrane proteins through sequential proteolysis. RIP typically starts with ectodomain shedding of membrane proteins by extracellular membrane-bound proteases followed by intramembrane proteolysis of the resulting membrane-tethered fragment. However, for the majority o...

INTRODUCTION The clinical feasibility of noninvasive imaging of interstitial alterations after myocardial infarction (MI) was assessed using a technetium-99m-labeled RGD imaging peptide (RIP). In experimental studies, RIP has been shown to target integrins associated with collagen-producing myofibroblasts (MFB). METHODS AND RESULTS Ten patients underwent myocardial perfusion imaging (MPI) wit...

We propose kernel block restricted isometry property (KB-RIP) as a generalization of the well-studied RIP and prove a variety of results. First, we present a “sumof-norms”-minimization based formulation of the sparse recovery problem and prove that under suitable conditions on KB-RIP, it recovers the optimal sparse solution exactly. The Group Lasso formulation, widely used as a good heuristic, ...

Ribosome-inactivating proteins (RIP) are a family of plant enzymes for which a unique activity was determined: rRNAN-glycosidase at a specific universally conserved position, A4324in the case of rat ribosomes. Recently we have shown that the RIP from Saponaria officinalis have a much wider substrate specificity: they are actually polynucleotide:adenosine glycosidases. Here we extend studies on ...

Ligation of the extracellular domain of the cell surface receptor Fas/APO-1 (CD95) elicits a characteristic programmed death response in susceptible cells. Using a genetic selection based on protein-protein interaction in yeast, we have identified two gene products that associate with the intracellular domain of Fas: Fas itself, and a novel 74 kDa protein we have named RIP, for receptor interac...

Receptor-interacting protein (RIP) has been reported to associate with tumor necrosis-associated factor (TRAF)2 and TRAF6. Since TRAF2 and TRAF6 play important roles in CD40 signaling and TRAF6 plays an important role in TLR4 signaling, we examined the role of RIP in signaling via CD40 and TLR4. Splenocytes from RIP(-/-) mice proliferated and underwent isotype switching normally in response to ...