BACKGROUND Pulmonary arterial hypertension (PAH) is a proliferative arteriopathy associated with a glycolytic shift during heart metabolism. An increase in glycolytic metabolism can be detected in the right ventricle during PAH. Expression levels of glycolysis genes in the right ventricle during glycolysis that occur in monocrotaline (MCT)-induced pulmonary hypertension (PH) remain unknown. M...

introduction: cardiovascular abnormalities have been reported in liver cirrhosis (lc). in these patients, cardiac symptoms and physical signs occur as the liver functions worsen. cirrhosis is associated with hyper dynamic circulation and beta-adrenergic system changes responsible for the cardiovascular abnormalities. the purpose of the present study was to explore the echocardiographic findings...

We hypothesized the coordinate induction of mitochondrial regulatory genes in the hypertrophied right ventricle to sustain mitochondrial respiratory capacity and contractile function in response to increased load. Wistar rats were exposed to hypobaric hypoxia (11% O(2)) or normoxia for 2 wk. Cardiac contractile and mitochondrial respiratory function were separately assessed for the right and le...

Right ventricular failure (RVF) is the most important prognostic factor for both morbidity and mortality in pulmonary arterial hypertension (PAH), but also occurs in numerous other common diseases and conditions, including left ventricle dysfunction. RVF remains understudied compared with left ventricular failure (LVF). However, right and left ventricles have many differences at the morphologic...

Right ventricular cavity electrocardiograms were obtained in six subjects having qR patterns in V leads made from precordial sites overlying the hypertrophied right ventricle. Four of the six, unlike control subjects, had no initial R wave in the right ventricular cavity; one had only a questionable initial R wave. Simultaneous intracavity and precordial electrocardiograms suggested that the in...

OBJECTIVES The purpose of this study was to verify in a long-term follow-up whether frequent monomorphic right ventricle extrasystoles may progress to arrhythmogenic right ventricular dysplasia (ARVD). BACKGROUND Frequent monomorphic right ventricle extrasystoles are generally considered benign. However, in patients with this pattern, cardiac magnetic resonance (MR) has recently shown anatomi...

Right ventricular (RV) diastolic dysfunction is an important indicator for the assessment of heart failure. Abnormalities in RV diastolic function underlie many pathologies. However, the underlying mechanisms remain poorly described, because the term is used to describe many variants in diastolic pathophysiology and function. Since the right ventricle is coupled to the pulmonary circulation wit...

The hearts from 31 fetuses aged from 12 to 40 weeks' gestation were dissected after fixation. The right ventricle and the left ventricle plus septum were weighed separately and a ratio was established. The total and separate ventricular weights increase steadily with age and at a similar rate. Throughout fetal life the left ventricle plus septum is larger than the right ventricle, but the right...

In sicker hearts, right atrial pressure (an estimation of right ventricle preload) are not equivalent to left atrial pressure (an estimation of left ventricle preload). Both right and left atrial pressures are frequently estimated using invasive techniques and also transthoracic echocardiography. While right atrial pressure is easy to obtain with transthoracic echocardiography, the assessment o...