This study aimed to examine olfactory mucosal changes in a rat model of acute rhinosinusitis and to determine how acute rhinosinusitis induces dysosmia. Total 100 rats were divided into the experimental (N = 80) and control (N = 20) groups. An acute rhinosinusitis model was established in the experimental rats. From the experimental group, 20 rats each were sacrificed at 1, 2, 3, or 4 weeks. Th...

Chronic rhinosinusitis is one of the most common chronic diseases with multi-factorial origin and different underlying pathophysiologies that has a great impact on quality of life with. It is generally agreed that there are many subgroups or “phenotypes” of chronic rhinosinusitis defined by clinical observable characteristics, such as the presence or absence of nasal polyps. These phenotypes ar...

INTRODUCTION Antibiotics are frequently used for the treatment of rhinosinusitis. Concerns have been raised regarding the adverse effects of antibiotics and growing resistance. The lack of development of new antibiotic compounds has increased the necessity for exploration of non-antibiotic compounds that have antibacterial activity. Amlodipine is a non-antibiotic compound with anti-inflammatory...

Although most cases of acute rhinosinusitis are caused by viruses, acute bacterial rhinosinusitis is a fairly common complication. Even though most patients with acute rhinosinusitis recover promptly without it, antibiotic therapy should be considered in patients with prolonged or more severe symptoms. To avoid the emergence and spread of antibiotic-resistant bacteria, narrow-spectrum antibioti...

Chronic rhinosinusitis is among the most common chronic diseases. It presents a major financial burden to the health care system [1], not to mention the burden of personal suffering and morbidity to the patient with debilitating chronic rhinosinusitis. Chronic rhinosinusitis is not a uniform entity, and its clinical presentations and etiologies may vary. Environmental factors predispose patient...

The concept of united airway disease interaction, which comprises chronic rhinosinusitis and other lower disorders such as asthma, has been recognized for over a decade [...]

OBJECTIVE To investigate the correlation of nasal septal deviations and chronic rhinosinusitis. METHODS The study was conducted at Department of Otolaryngology, Head and Neck Surgery, Boali Hospital, Sari, Iran from January 2012 to September 2014 and comprised subjects aged from 5 to 68 years who had undergone elective functional endoscopic sinus surgery for chronic rhinosinusitis. SPSS 17 wa...

Rhinosinusitis is a feature of aspirin-exacerbated respiratory disease (AERD), which in the initial phase is manifested as nasal congestion, mostly affecting females at the age of around 30 years on average. Subsequently, nasal inflammation progresses to chronic eosinophilic rhinosinusitis, asthma, nasal polyposis, and intolerance to aspirin and to other NSAIDs. While it has been long establish...