BACKGROUND To investigate the associations between HLA-DRB1 shared epitope (SE) alleles and rheumatoid arthritis in subsets of rheumatoid arthritis defined by autoantibodies in three Asian populations from Malaysia. METHODS 1,079 rheumatoid arthritis patients and 1,470 healthy controls were included in the study. Levels of antibodies to citrullinated proteins (ACPA) and rheumatoid factors wer...

From 80 % to 90 of foot deformities in adults are due rheumatoid arthritis. Despite various surgical approaches, early functional and cosmetic results have been the greatest concern among patients. Thus, optimal choice forefoot correction is vital importance for better subjective clinical results. Our work evaluates minimally invasive surgery (MIS) resection arthroplasty per Hoffmann-Clayton al...

We studied emotional health in patients with diabetes mellitus (n = 89) or rheumatoid arthritis (n = 100) aged 18-65 years, at the time of diagnosis and after 24 months. Predictors for depression or anxiety according to the Hospital Anxiety and Depression scale after 2 years were assessed by logistic regression, with psychosocial factors and coping as dependent factors. There were many similari...

introduction: to determine the prevalence of depressive disorder and it's related factors in the patients with rheumatoid arthritis. methods: this cross-sectional study was conductd from april 2013 to august 2014.a total of 81 patients with rheumatoid arthritis (ra) were enrolled from rheumatology clinic, shahid beheshti hospital, kashan/ iran. the severety of depressive disorder was measured b...

OBJECTIVES To estimate the complement activating properties of monoclonal, monoreactive, and polyreactive IgM rheumatoid factors derived from Epstein-Barr virus transformed B cells isolated from peripheral blood and synovial tissue of patients with rheumatoid arthritis (RA). METHODS An enzyme linked immunosorbent assay (ELISA) was used to measure the activation of the classical pathway of com...

BACKGROUND Rheumatoid arthritis may be associated with an increased risk of cardiovascular disease. We compared the incidence rates of myocardial infarction and stroke in subjects with and without rheumatoid arthritis. METHODS AND RESULTS A prospective cohort study was conducted among the 114 342 women participating in the Nurses' Health Study who were free of cardiovascular disease and rheum...

rheumatoid factors (rf) are autoantibodies with specificity for the fc portion of human igg. production of rf is a characteristic feature of rheumatoid arthritis (ra) and is detectable in high titer in about 90% of these patients. in this study, we measured total igm, iga, igmrf and igarf in serum and synovial fluid of 45 ra patients by elisa and the results were compared with those obtained by...

background: this study aimed to compare the percentage of detection of periarthritis in patients with rheumatoid arthritis using clinical examination and ultrasound methods. materials and methods: this study is a cross?sectional study which was conducted in al?zahra hospital (isfahan, iran) during 2014–2015. in our study, ninety patients were selected based on the american college of rheumatolo...