The cytochrome P450 protective activity of Sapindus mukorossi and Rheum emodi were evaluated against CCl4 induced prolongation of pentobarbitone sleep time in Wister rats. The fractions, at a dose of 0.2 g/kg,0.4g/kg p.o., Sapindus mukorossi, Rheum emodi significantly prevents the CCl4 induced prolongation of pentobarbitone sleep time (P<0.01), indicating the cytochrome P450 protection activity...

In recent years, large controlled trials have tested several new agents for systemic lupus erythematosus (SLE). Unfortunately, none of these trials has met its primary outcome. This does not mean progress has not been made. In fact, a great deal has been learned about doing clinical trials in lupus and about the biological and clinical effects of the drugs being tested. Many of these drugs were...

MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction. Nat Genet 2005;37:486–94. 4 Yazdani-Biuki B, Brickmann K, Wohlfahrt K et al. The MHC2TA -168A>G gene polymorphism is not associated with rheumatoid arthritis in Austrian patients. Arthritis Res Ther 2006;8:R97. 5 Orozco G, Robledo G, Linga Reddy MV et al. Study of the role of a func...

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When CASNET (Chapter 7) evolved into the general s,vstem-building tool known as EXPERT, one of the first applications was a rheumatology consultant program called AI/Rheum (Kingsland and Lindberg, 1983). Developed collaboratively by researchers at Rutgers University and the University of Missouri, AI/Rheum quickly became large and complex, thereby complicating the process of knowledge base main...

levede M. Relevance of urinary excretion of alcian blue-glycosaminoglycans complexes and hydroxyproline to disease activity in rheumatoid arthritis. J Rheumatol 1982;9: 579-83. 16. Chuck AJ, Murphy J, Weiss JB, Greenan DM. Comparison of urinary glycosaminoglycan excretion in rheumatoid arthritis, osteoarthritis, myocardial infarction, and controls. Ann Rheum Dis 1986;45:162-6. 17. Moss DW. Alka...

S19–23. 13 Desai SR, Veeraraghavan S, Hansell DM, Nikolakopolou A et al. CT features of lung disease in patients with systemic sclerosis: comparison with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia. Radiology 2004;232:560–7. 14 Wells AU, Hansell DM, Haslam PL, Rubens MB et al. Bronchoalveolar lavage cellularity: lone cryptogenic fibrosing alveolitis compared with the fi...

BACKGROUND Exposure to ultraviolet (UV) radiation causes various forms of acute and chronic skin damage, including immunosuppression, inflammation, premature aging and photodamage. Furthermore, it induces the generation of reactive oxygen species, produces proinflammatory cytokines and melanocyte-stimulating hormone (MSH) and increases tyrosinase activity. The aim of this study was to evaluate ...