Hyaluronan is a linear glycosaminoglycan that has received special attention in the last few decades due to its extraordinary physiological functions. This highly viscous polysaccharide is not only a lubricator, but also a significant regulator of cellular behaviors during embryogenesis, morphogenesis, migration, proliferation, and drug resistance in many cell types, including stem cells. Most ...

Immunohistochemical analysis of skin tissue biopsies from an individual with acute graft-versus-host-disease. Scattered ICOS+ activated lymphocytes were observed at the dermo-epidermal junction, superficial dermis and around the adnexal follicular epithelium. Figure taken from the article by Maria Cuzzola and colleagues on page 1532. Widespread over-expression of the non-clustered homeobox gene...

Hyaluronic acid (HA) is abundant in tumor microenvironment and closely associated with invasiveness of glioblastoma (GBM) cells. However, the cellular mechanism underlying HA-rich microenvironment in GBM remains unexplored. Here, we show that tumor-associated mesenchymal stem-like cells (tMSLCs) contribute to abundance of hyaluronic acid (HA) in tumor microenvironment through HA synthase-2 (HAS...