The mRNA export complex TREX (TREX) is known to contain Aly, UAP56, Tex1 and the THO complex, among which UAP56 is required for TREX assembly. Here, we systematically investigated the role of each human TREX component in TREX assembly and its association with the mRNA. We found that Tex1 is essentially a subunit of the THO complex. Aly, THO and UAP56 are all required for assembly of TREX, in wh...

results the median level of pbmcs htert mrna in survivors increased with treatment time and was significantly higher than the corresponding level in non-survivors after 14 days of treatment (p < 0.001). subgroup analyses showed that the levels of pbmcs htert mrna were remarkably higher in patients with acute-on-chronic liver failure than in those with chronic liver failure (p < 0.05). in patien...

background: sodium arsenite (naaso2) has potent cytotoxic activity in human cancer cells. oxidative stress has been suggested as a mechanism for arsenic-induced carcinogenesis. the purpose of the present study was to evaluate the alteration of mrna levels of catalase ( cat ) and superoxide dismutase 2 ( sod2 ) in mcf-7 and jurkat cells after exposure to naaso 2 . methods: methylthiazol tetrazol...

The important worldwide forage crop red clover ( Trifolium pratense L.) is widely cultivated as cattle feed and for soil improvement. Wild populations landraces have great natural diversity that could be used to improve clover. However, date, there still insufficient knowledge about the genetic phenotypic of species. Here, we developed a low-cost complexity reduced mRNA analysis (mRNA-GBS) comp...

nitrate is one of the major sources of nitrogen for the growth of plants. it is taken up by plant roots and transported to the leaves where it is reduced to nitrite in the. the main objective of this research was to investigate stimulatory effects of sodium nitrate, potassium nitrate, ammonia and urea on the production/generation of the nitrate reductase mrna in triticum aestivum plants. the pl...

background sall gene family represent a group of evolutionary conserved zinc finger transcription factors which are involved in normal development. it includes four members (sall1 to sall4). sall4 has significant roles in the maintenance of pluripotency and self-renewal, efficient proliferation /stabilization and cell fate decision of embryonic stem cells (escs). our aim in this study was to an...

The mRNA export adaptors provide an important link between multiple nuclear mRNA processing events and the mRNA export receptor TAP/NXF1/Mex67p. They are recruited to mRNA through transcriptional and post-transcriptional events, integrating this information to licence mRNA for export. Subsequently they hand mRNA over to TAP and switch TAP to a higher-affinity RNA-binding state, ensuring its sta...