Basal cell carcinoma (BCC) is the most common non-melanoma skin cancers, Giant variant of BCCs are a rare cutaneous neoplasms. The most important risk factors for skin cancers are ultraviolet (UV) exposure. We report the case of a 69-year-old men presented with pruritus, bleeding, focal ulcerated, large multinodular lesion symptoms and findings in the temporal region of the scalp. Grossly, ther...

Osteoclast-like giant cell tumor of the pancreas is a rare non-endocrine neoplasm composed of reactive multinucleated giant cells admixed with mononuclear stromal cells. We report a case of osteoclast-like giant cell tumor of the pancreas in a 58-year-old female with vague clinical symptoms. Endoscopic ultrasound-guided aspirate from the mass revealed numerous characteristic osteoclast-like gia...

small cell carcinoma of the urinary bladder (sccub) is an extremely rare bladder malignancy characterized by an aggressive clinical behavior. so, it is important to diagnose this high grade disease by urinary cytology. we report a case of sccub in an old man with chronic lymphocytic leukemia (cll) in remission, while bladder tumor was diagnosed by cytology. with this article, we aimed to review...

t regulatory cells play a crucial role in immunological unresponsiveness to self- antigens and in suppressing excessive immune responses deleterious to the host. t regulatory cells are produced in the thymus as a functionally mature subpopulation of t cells. they can be induced from naive t cells in the periphery and express their marker as a forkhead/winged helix transcription factor called fo...

CONTEXT The combination of an osteoclastic giant cell tumor and a pleomorphic giant cell carcinoma of the pancreas is distinctly unusual and is associated with an adverse outcome. The origin of these two components within a tumor has long been debated based on the immunohistochemical and ultra-structural analysis. CASE REPORT Herein we describe a tumor with amalgamation of these two distinct ...

The authors report on a rare case of metachronous, multicentric giant cell tumor of bone in a young woman. The first lesion occurred in the right fibular head at 26 years of age, which was surgically treated. Twenty-seven months later, the second lesion developed in the right rib, and the patient underwent an excision of the tumor. Histologically, both tumors showed typical appearance of conven...

purpose: to present a case of orbital granular cell tumor, a rare orbital tumor. case report: a 55-year-old woman presented with binocular diplopia and right ocular displacement. the problem had initiated 3 years ago. a firm nontender mass at the region of the right lower lid was visible. orbital ct-scan disclosed a well-defined mass in the inferior right orbit with involvement of the inferior ...

Giant cell tumor of soft tissue is a rare tumor first described by Salm and Sissons in 1972 as being a distinct entity.(1) Histologically, it is composed of multinucleated giant cells dispersed among mononuclear cells, and is indistinguishable from its bone equivalent.(2) The majority of these tumors have been reported to occur in the lower extremity.(2,3) We describe a case of giant cell tumor...

Solitary fibrous tumor (SFT) is a rare mesen­chymal tumor of the pleura, which arises from visceral pleura and projects into the pleural cavity. This tumor is not related to asbestos exposure or cigarette smoking (1). We report a rare case of SFT of the lung. In this case report, we present the case of a giant SFT in a 76-year-old woman who presented with the complaint of chest pain on the left...

  Background: Tumors involving the hand skeleton are rare. However, a basic knowledge of hand tumors is necessary for every clinician. This is due to the importance of distinguishing typical benign tumors from life or limb threatening malignant ones. Methods: This study is a review of 99 cases of osseous hand tumors presented to the department of orthopedic surgery, Imam Khomeini Hospital in Te...