نتایج جستجو برای: reverse transcriptase inhibitor

تعداد نتایج: 313286  

2013
Mamta Sharma Louis D. Saravolatz

Rilpivirine is a new non-nucleoside reverse transcriptase inhibitor (NNRTI) that is approved for HIV-1 treatmentnaive adult patients in combination with other antiretroviral agents. The recommended dose is a 25 mg tablet once daily taken orally with a meal. Due to cytochrome P450 3A4 enzyme induction or gastric pH increase, rilpivirine cannot be coadministered with a number of other drugs (anti...

Journal: :The Journal of antimicrobial chemotherapy 2009
Lucy Garvey Alan Winston

Combination antiretroviral therapy has transformed the prognosis and life expectancy of HIV-1 infected individuals in resource-rich settings. British guidelines currently recommend the non-nucleoside reverse transcriptase inhibitor (NNRTI) efavirenz as part of first-line treatment in therapy-naive HIV-1 infected individuals. However, efavirenz is limited by its low genetic barrier to the develo...

2015
Darren M. Moss Neill J. Liptrott Marco Siccardi Andrew Owen

The SLC22A1 influx transporter is expressed on the basolateral membrane of hepatocytes and is involved in the excretion of numerous cations. Inhibition of SLC22A1 by several antiretrovirals, such as the protease inhibitor darunavir, has not previously been determined. In order to better understand and predict drug-SLC22A1 interactions, a range of antiretrovirals were screened for SLC22A1-associ...

Journal: :The Journal of antimicrobial chemotherapy 2008
Christoph Wyen Heidy Hendra Martin Vogel Christian Hoffmann Heribert Knechten Norbert H Brockmeyer Johannes R Bogner Jürgen Rockstroh Stefan Esser Hans Jaeger Thomas Harrer Stefan Mauss Jan van Lunzen Nicole Skoetz Alexander Jetter Christiane Groneuer Gerd Fätkenheuer Saye H Khoo Deirdre Egan David J Back Andrew Owen

OBJECTIVES The aim of this study was to investigate the frequency of CYP2B6 polymorphisms (according to ethnicity) and the influence of heterozygosity and homozygosity on plasma concentrations of efavirenz and nevirapine. METHODS Following written informed consent, 225 Caucasians and 146 Blacks were recruited from the German Competence Network for HIV/AIDS. Plasma concentrations of efavirenz ...

2009

76 P&T® • February 2008 • Vol. 33 No. 2 NEW DRUGS Etravirine (Intelence) For HIV Infection Etravirine tablets (Intelence, Tibo tec/Ortho) have been approved by the Food and Drug Administration (FDA) after a priority review. This drug is indicated for the treatment of human immunodefieincy virus (HIV) infection in adults who have not responded to other antiretroviral agents. Etravirine is a non-...

Journal: :Antiviral therapy 2012
Mark Naccarato Deborah Yoong Colin Kovacs Kevin Gough

The cytochrome P450 isoforms primarily involved in clobazam metabolism are CYP3A4 and 2C19. Drugs that modulate these enzymes would then be expected to alter the exposure of clobazam and its major metabolites. Etravirine, a second-generation non-nucleoside reverse transcriptase inhibitor has been shown to induce CYP3A4, while inhibiting CYP2C9 and CYP2C19. We report a case in which a potential ...

2015
Thesla Palanee-Phillips Katie Schwartz Elizabeth R. Brown Vaneshree Govender Nyaradzo Mgodi Flavia Matovu Kiweewa Gonasagrie Nair Felix Mhlanga Samantha Siva Linda-Gail Bekker Nitesha Jeenarain Zakir Gaffoor Francis Martinson Bonus Makanani Sarita Naidoo Arendevi Pather Jessica Phillip Marla J. Husnik Ariane van der Straten Lydia Soto-Torres Jared Baeten Rupert Kaul

INTRODUCTION Women in sub-Saharan Africa are a priority population for evaluation of new biomedical HIV-1 prevention strategies. Antiretroviral pre-exposure prophylaxis is a promising prevention approach; however, clinical trials among young women using daily or coitally-dependent products have found low adherence. Antiretroviral-containing vaginal microbicide rings, which release medication ov...

Journal: :Antiviral therapy 2009
John E McKinnon John W Mellors Susan Swindells

Current U.S. guidelines for initial therapy of HIV type-1 (HIV-1) infection recommend daily, lifelong treatment with a combination of three antiretroviral drugs consisting of two nucleoside analogue reverse transcriptase inhibitors and a non-nucleoside reverse transcriptase inhibitor or a protease inhibitor. Although this approach has been successful in reducing morbidity and mortality from HIV...

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