PURPOSE To determine factors affecting the disc-fovea angle (DFA), and to test the hypotheses that adjusting for DFA improves limits of retinal nerve fiber layer (RNFL) variability in normal subjects or enhances performance of RNFL measures for glaucoma detection. METHODS Disc-fovea angle was measured on scanning laser ophthalmoscope fundus images from 170 eyes (110 normal and glaucoma subjec...

Optical coherence tomography (OCT) is an emerging clinical and research measure of retinal nerve fiber layer (RNFL) loss in multiple sclerosis (MS) and may reflect neurodegeneration. Few studies capture the effect of disease duration on the RNFL in subjects without exposure to disease-modulating therapies.We assessed the relationship of RNFL loss with disease duration in subjects with untreated...

Structural damage in glaucoma often occurs before detectable loss in visual function.1-3 Accurate assessment of the optic disk and retinal nerve fiber layer (RNFL) morphology, however, is not always an easy task. Optical coherence tomograph (OCT), confocal scanning laser ophthalmoscope (CSLO) and scanning laser polarimeter (SLP) are the 3 commonly used imaging instruments for objective measurem...

BACKGROUND Qualitative description of the optic disc has clinical value, but optical coherence tomography (OCT) has provided the ability to quantify retinal nerve fiber layer (RNFL) thickness. METHODS We asked three neuro-ophthalmologists of at least 20 years' experience to estimate the average OCT RNFL thickness of 37 eyes based on fundus photos. RESULTS The overall correlation coefficient...

BACKGROUND Optical coherence tomography (OCT) is a simple, high-resolution technique to quantify the thickness of retinal nerve fiber layer (RNFL) and macula volume, which provide an indirect measurement of axonal damage in multiple sclerosis (MS). This study aimed to evaluate OCT finding in relapsing-remitting MS patients of the northwest of Iran and compare them with a normal control group. ...

PURPOSE Aim of the present study was to evaluate whether there is a correlation between retinal blood vessel density (RVD) and the peripapillary retinal nerve fiber layer (RNFL) thickness profile. METHODS RNFL thickness of 106 healthy subjects was measured using scanning laser polarimetry, GDx variable corneal compensation (VCC), and GDx enhanced corneal compensation (ECC). A proprietary soft...

PURPOSE To present full ophthalmologic examination and retinal nerve fiber layer (RNFL) photographs of autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) patients showing significant increases in RNFL thickness compared to healthy subjects, but without myelinated retinal fibers. METHODS The study design was observational case series. Ten eyes of five patients with molecular co...

PURPOSE To measure and describe the reflectance properties of a mammalian retinal nerve fiber layer (RNFL) and to determine the mechanisms responsible for the RNFL reflectance. METHODS An isolated rat retina suspended across a slit in a black membrane and mounted in a black perfusion chamber provided high quality images of the RNFL. Imaging microreflectometry was used to measure RNFL reflecta...

AIM To compare retinal artery-vein diameters (RAVDs) of patients with pseudoexfoliation (PSX) syndrome with healthy controls and investigate the correlations between retinal nerve fiber layer (RNFL) thickness parameters and RAVDs. METHODS Seventeen eyes with PSX and 17 eyes of age-matched controls were included in the study. All participants underwent routine ophthalmological examination, Hum...

Purpose. To evaluate the relationship between the macular ganglion cell complex (mGCC) thickness, which is the sum of the retinal nerve fiber, ganglion cell, and inner plexiform layers, measured with a spectral-domain optical coherence tomograph and the optic nerve head topography measured with a confocal scanning laser ophthalmoscope in glaucomatous eyes with visual field defects localized pre...