background: metastasis is one the most leading cause of death from cancer. the chemokine receptor of cxcr4 has an important role in cell migration and cancer metastasis. additionally, metastasis is always associated with the process of epithelial-mesenchymal transition (emt). in this study the correlation between expression of cxcr4 and emt-tfs has been examined. methods: the expression of cxcr...

despite the high rate of prostate cancer, the incidence of penile metastasis originating from prostate cancer is extremely rare, especially in the form of peyronie’s disease. moreover, brain metastasis, which is caused by prostate cancer, is not a common phenomenon and occurs mostly in older patients. herein, we report a case of a middle-aged man with penile and brain metastasis originating fro...

it has been reported that cxcl12 binding to cxcr4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on mcf-7 and mda-mb-23...

adenosquamous carcinomas of stomach are rare entities comprising 0.5% of stomach carcinomas. here, we report a case of a 50-year-old female, who presented with weakness, pallor, and symptoms of gastric outlet obstruction. a partial gastrectomy was done and histology showed evidence of adenosquamous carcinoma of the antrum with metastasis to the perigastric lymph nodes. the patient condition imp...

malignant tumors of pancreas are usually primary neoplasms and pancreatic metastases are rare findings. we are reporting a case of squamous cell carcinoma (scc) of the esophagus with pancreatic metastasis. a 59-year old woman was admitted with chief complaint of abdominal pain and mass. she was a known case of esophageal scc since 4 years before when she had undergone transthoracic esophagectom...

the presence of a low level of m protein in the peripheral blood

adenoid cystic carcinoma (adcc) is a malignant neoplasm, which accounts for 5-10% of all salivary gland tumors (1). about 50% of these tumors originate from intraoral minor salivary glands usually in the hard palate (1). three clinically obvious characteristics of adcc include slow growth rate, perineural invasion and high incidence of distant metastasis (1). the most commonly-affected sites of...

background: sentinel  lymph  node  biopsy  has  shown  to  be  a  good  alternative procedure  for  axillary  lymph  node  dissection  and  to lead  to  lower  frequency  of morbidity, though this technique has its own side effects. it needs especial equipment and may not be available in some medical centers, especially in developing countries. this study aimed to identify a subgroup of patient...

results: among 11 patients who underwent surgery consisted of eight males and three females. their metastasis originated from testis tumors (n = 5), renal cell carcinoma (rcc; n = 4), bladder tumor (n = 1), and prostate cancer (n = 1). their mean age was 41.27 years (range, 21-67). the mean age of the patients with rcc and testis tumor at the time of diagnosing metastasis was 54 and 24.8 years,...