In 2 infants who had received Intralipid fat emulsion as part of a total parenteral hyperalimentation regimen, a pigmented material was deposited in the macrophages of their reticuloendothelial systems. The histochemical characteristics of this pigment were similar to those seen after experimental infusion of fat emulsions. The possible implications of this finding and its effect on host resist...

Therapeutic peptides (TPs) are a class of peptide-based agents capable of eliciting a therapeutic response by modulation of targets within or on the surface of cells. TPs are advantageous because they are amenable to rational design, they have high specificity for their targets and can be made to target almost any protein of interest, including proteins for which we have no small-molecule drugs...

HYPOTHESIS Reticuloendothelial system function is altered in patients with multiple trauma and organ failure. DESIGN Prospective cohort study. SETTING Surgical intensive care unit at a level I trauma center. PATIENTS Patients with multiple blunt trauma and injury severity scores greater than 20, with no referrals. INTERVENTIONS Every second day reticuloendothelial system (RES) clearance...

Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal disorder characterized by abnormal activation of macrophages and occurring in many conditions in all age group. It is also characterized by hemophagocytosis in the bone marrow and in the reticuloendothelial system (RES). The underlying mechanism of acquired HLH is associated with uncontrolled inflammatory reaction which in...

A 26-year-old male with ataxia-telangiectasia died with a gastric adenocarcinoma. Malignancy is a recognised complication of this condition, the majority of cases being reticuloendothelial. There have been three reports of gastric adenocarcinoma associated with ataxia-telangiectasia; this, however, is the first in British published reports.

The phagocytic capacity of the reticuloendothelial system was studied by the clearance from the plasma of microaggregated iodinated human serum albumin. About half of the patients with cholestasis showed impaired Kupffer-cell phagocytosis. The finding may be relevant to the occurrence of surgical complications in patients with obstructive jaundice.