For nearly 4 years a search has been conducted in our laboratories among materials of natural origin for agents having the ability to retard the growth of tumors. Early in the course of this in vestigation crude culture filtrates of the fungus Aspergillus fumigatus were found to retard the growth of the Crocker mouse sarcoma 180 and of the mammary adenocarcinoma E 0771 in mice (4). Meanwhile, K...

A great deal of Retarding Field Analyzer (RFA) data has been taken as part of the CesrTA program at Cornell. Obtaining a quantitative understanding of this data requires use of cloud simulation programs, as well as a detailed model of the RFA itself. In a drift region, the RFA can be modeled by postprocessing the output of a simulation code, and one can obtain best fit values for important simu...

Background/Aims:. The aim of this study was to elucidate the effects of glucose restriction (GR) on cell replicative senescence in vitro by human diploid fibroblasts IMR-90. Methods: IMR-90 cells were cultured under 40, 60% GR or high glucose medium and biomarkers of cell senescence were compared with cells cultured in normal glucose medium (5.5 mM glucose). The impact of different concentratio...

The role of heart rate in the development of coronary atherosclerosis was assessed in adult male cynomolgus monkeys (Macaca fascicularis). Heart rate was lowered in six animals by surgical ablation of the sinoatrial node. A sham procedure, which included all of the surgical steps except for sinoatrial node ablation, was carried out in eight animals. All of the monkeys were fed an atherogenic hi...