INTRODUCTION The peroxisome proliferator-activated receptor-γ agonists rosiglitazone and pioglitazone activate glucocorticoid receptors and have an immunomodulatory effect. The authors aimed to systematically determine the risk of pneumonia or lower respiratory tract infections associated with thiazolidinediones. METHODS Systematic searches of MEDLINE, EMBASE, regulatory documents and trial r...

Dendritic cells located at the body surfaces, e.g. skin, respiratory and gastrointestinal tract, play an essential role in the induction of adaptive immune responses to pathogens and inert antigens present at these surfaces. In the respiratory tract, multiple subsets of dendritic cells (RDC) have been identified in both the normal and inflamed lungs. While the importance of RDC in antigen trans...

BACKGROUND Mycobacterium chimaera is a recently described species within the Mycobacterium avium complex. Its pathogenicity in respiratory tract infection remains disputed. It has never been isolated during cystic fibrosis respiratory tract infection. CASE PRESENTATION An 11-year-old boy of Asian ethnicity who was born on Réunion Island presented to our hospital with cystic fibrosis after a d...

AIMS To establish the prevalence and clinical correlates of HIV among children with acute lower respiratory tract infection. METHODS Children admitted to a rural Zambian hospital were studied over an eight month period. The diagnosis of acute lower respiratory tract infection was made clinically, according to World Health Organisation (WHO) criteria. Clinicians, who were unaware of the childr...

conclusions mp, flub and rsv are the principal contributors to ari in the hubei area, with mixed infections, typically of mp and flub, being the most common pathogens statistically significant between different age groups. background acute respiratory infection (ari) is one of the primary diseases that cause high morbidity and mortality to children especially in developing countries. ari can co...

pneumonia is the leading cause of mortality in young children worldwide. early diagnosis and empiric antibacterial therapy is an important strategy to improve outcome. the world health organization (who) has developed case management guidelines to reduce pneumonia-related deaths through early diagnosis and antibiotic treatment. for management purpose, pneumonia is subclassified by its severity....

The role of viral respiratory tract infections in acute exacerbations of asthma was studied prospectively in 31 patients with atopic asthma aged 15-56 years. Patients recorded symptom scores for asthma and peak expiratory flow rate daily for 11 months. In addition, they reported for detailed clinical, functional, and virological study every four weeks and as soon as possible after the onset of ...