ATP-binding cassette sub-family G member 5 (ABCG5) and ABCG8 are members of an ATP-binding cassette transporter superfamily. ABCG5 and ABCG8 variants affected serum levels of cholesterol and were considered as risk factors for coronary heart disease (CHD). The present control study analyzed ABCG5 and ABCG8 variants in a population for association with the risk of CHD. A total of 417 CHD patient...

The altered amino acid (AA) levels as neurotransmitter closely correlate to neurodegenerative conditions including Alzheimer's disease (AD). Target profiling analysis of nineteen AAs in brain cortex samples from three Tg2576 mice as AD model and three littermate mice as control model was achieved as their N(O,S)-ethoxycarbonyl/tert-butyldimethylsilyl derivatives by gas chromatography. Subsequen...

Polymorphic variants of genes involved in folate metabolism are implicated in the susceptibility to meningioma and glioma, but the results from published articles are controversial and inconclusive. Therefore, we performed this meta-analysis including all studies available to evaluate the relationship between folate metabolism genetic polymorphisms and the susceptibility to meningioma and gliom...

OBJECTIVES The study investigated the species distribution, antibiotic susceptibility patterns and genotypic resistance characteristics of 113 consecutive blood culture isolates of Acinetobacter species collected between 2005 and 2007 throughout Norway. METHODS Species identification was performed by partial rpoB sequence analysis, and verified by 16S rDNA and recA sequence analyses. Suscepti...

Human genome-wide association studies have revealed a large number of genomic loci linked to cardiometabolic disease traits. However, for many of the gene variants identified, it remains unknown how they functionally influence the disease phenotype or whether these genes represent new therapeutic targets. Single-nucleotide polymorphisms in FADS1, which encodes Δ-5 fatty acid desaturase, have be...

The objective of this study was to evaluate myostatin (MSTN) gene by polymerase chain reaction -restriction fragment length polymorphism (PCR-RFLP) and sequencing methods in four goat breeds including Mohabadi, Markhoz, Lori and Bital breeds. A573 bp fragment of MSTN gene was amplified by PCR. A new 5 bp deletion in 5`UTR (206TTTTA) of the MSTN gene was directly identified by sequencing. The AA...

A wild-type nucleopolyhedrovirus (NPV) isolate from Spodoptera exigua from Florida (Se-US2) is a variant of the SeMNPV type strain since it has a unique DNA profile but is closely related to other known geographical isolates of SeMNPV. It consists of several genotypic variants, of which seven were identified in a Se-US2 virus stock by a modification of the in vivo cloning method developed by Sm...

Using the PCR technique, the presence of the seven genotypic virulence markers of Campylobacter has been tested. It was found that all C. coli (92 strains) and C. jejuni (105 strains) possessed the flaA and cadF markers. Several strains were positive for the CDT toxin genes (76.6%, 85.3%, and 83.2% strains with the A, B, and C cdt gene variants, respectively). On the other hand, only 66.0% and ...