PURPOSE Prostate-specific membrane antigen (PSMA) is a cell surface protein that is overexpressed in prostate cancer, including hormone-refractory and metastatic disease. Our goal in this study was to develop a series of PSMA-based imaging agents for clinical use. EXPERIMENTAL DESIGN We have synthesized and evaluated the in vivo biodistribution of two radiolabeled urea derivatives that have h...

The aim of the laboratory experiments presented here is to find a set of thermosensitive tracers to identify thermal characteristics in deep geothermal reservoirs during the long-term operation of a power plant. In the near future several short-term push-pull experiments are planned at different test-sites in northern Europe. As a first step we focus on tracers which fulfill the requirements of...

Fatty acid amide hydrolase (FAAH) is one of the main enzymes responsible for terminating the signaling of endocannabinoids, including anandamide. This paper is the first report of the synthesis, [123I]-labeling and in vitro and in vivo evaluation of anandamide analogues as potential metabolic trapping radioligands for in vivo evaluation of brain FAAH. N-(2-iodoethyl)linoleoylamide (2) and N-(2-...

This article discusses an efficient implementation of tensors of arbitrary rank by using some of the idioms introduced by the recently published C++ ISO Standard (C++11). With the aims at providing a basic building block for high-performance computing, a single Array class template is carefully crafted, from which vectors, matrices, and even higher-order tensors can be created. An expression te...

C++0x is the working title for the revision of the ISO standard of the C++ programming language that was originally planned for release in 2009 (but that will probably appear in 2011). The largest language extension in C++0x was “concepts”, that is, a collection of features for constraining template parameters. In September of 2008, the C++ standards committee voted the concepts extension into ...

Traditional nuclear medicine ligands were designed to target cellular receptors or transporters with a binding pocket and a defined structure-activity relationship. More recently, tracers have been developed to target pathological protein aggregations, which have less well-defined structure-activity relationships. Aggregations of proteins such as tau, α-synuclein, and β-amyloid (Aβ) have been i...