In this paper, I develop an industry-level index of capital-embodied R&D by capturing the extent of research and development directed at the capital goods in which a given industry invests. Compiling and adjusting data from the National Science Foundation and Commerce Department, I construct industry-level, time-series measures of this index and investigate its properties. The data allow me to ...

We have examined the effect of IL-12-producing cellular vaccines on the cytotoxicity and proliferative potential of CD45+ tumour-infiltrating cells (TIL) in mice carrying syngeneic TC-1 and TC-1/A9 HPV 16-associated tumours after chemotherapy with CBM-4A ifosfamide derivative. The chemotherapy resulted in the decrease of the CD4+ and CD8+ TIL, increase of the Gr-1+/CD11b+ TIL, no changes in the...

This work is concerned with the development and study of a minimum residual norm subspace method based on the generalized conjugate residual method with inner orthogonalization (GCRO) method that allows flexible preconditioning and deflated restarting for the solution of nonsymmetric or non-Hermitian linear systems. First we recall the main features of flexible generalized minimum residual with...

PROBLEM STATEMENT: The development of a potent vaccine that can help treat tumors resistant to conventional cytotoxic therapies remains elusive. While part of the problem may be that trials have focused on patients with bulky residual disease, the desire to maximize responses to the vaccine remains. APPROACH: The gamma(c) family of cytokines offer a unique opportunity to support the expansion ...

Components of mHealth are increasingly being added to development interventions worldwide. A particular case of interest is in Mali where the U.S. President's Malaria Initiative (PMI) Africa Indoor Residual Spraying (AIRS) Project piloted a mobile mass-messaging service in Koulikoro District in August 2014 to determine whether voice and/or text messages received on cell phones could effectively...

BACKGROUND AND OBJECTIVES Recent investigations in acute myeloid leukemia (AML) have clearly demonstrated that specific karyotypic abnormalities result in distinct biological and clinical entities. We focus on recent advances on biology and treatment of AML with t(8;21). DATA SOURCES AND METHODS The information presented here derives from literature data and experience of the authors. The mos...

We have examined the effect of the fractional concentration of nitrogen (FIN2) on the decrease in lung volumes which occurs during restricted breathing with oxygen-nitrogen mixtures. Conscious human subjects breathed one of five gas mixtures of oxygen and nitrogen for 15 min on each of five occasions. For the final 5 min of each 15-min period, functional residual capacity (FRC) was reduced by o...

The CD52-targeting antibody alemtuzumab is established in clinical practice with convincing activity in relapsed and refractory chronic lymphocytic leukemia (CLL), particularly in patients with high-risk features and adverse prognosis. In the CAM307 study alemtuzumab was tested and finally approved as a first-line single agent, even though the hurdle with chlorambucil as the contender was not s...

Distortion and deformation of tubes during machining operations are very important. In this study, a tube used in magnetic drum separator under concentrated load (machining load) is considered. Using finite element simulation, deformities and their dependence on parameters such as the thickness of the tube and the place of concentrated force are observed and predicted. To compare and confirm th...

The microbial quality of water plays a key role in community health. The present study aimed to determine the microbial quality of the drinking water distribution networks in the urban and rural areas of Dasht-e Azadegan County, Iran and assess the influential factors in the quality of drinking water.In this descriptive-analytical study, 907 drinking water samples were collected from the urban ...