This article explores the mechanisms of action and the potential responder profile of acamprosate, a compound efficacious in relapse prevention of alcoholism. New evidence at the molecular and cellular level suggests that acamprosate attenuates hyper-glutamatergic states that occur during early abstinence and involves iono (NMDA)- and metabotrotropic (mGluR5) glutamate receptors along with augm...

In this study, we examined the current practice and alternative methods for interpreting nonsignificant findings in psychological research. The traditional null-hypothesis testing presents a challenge for researchers to interpret nonsignificant findings. We reviewed the abstracts of all empirical articles published in three high-esteem psychological journals in 2015 and selected those which ref...

The number of centenarians in Japan has increased more than a hundred times over the past four decades, reaching nearly 20,000 persons currently. The rate of centenarians in the population is higher in the western part of Japan, where mortality from stroke is low. Centenarians generally have nutritionally well-balanced diets that are rich in animal food and vegetables. They tend to be extrovert...

All Atomic Weapons Employer employees who worked in any building at the Wah Chang facility in Albany, Oregon, for the operational period from January 1, 1971 through December 31, 1972, for a number of work days aggregating at least 250 work days, occurring either solely under this employment or in combination with work days within the parameters established for one or more other classes of empl...

A large part of the strength and power of TRIZ exists because the methodology was constructed on the foundations provided by the analysis of a substantial number of patents. Around 1985, however, this analysis was for the most part halted and the research focus was shifted to other important areas. In using some of the TRIZ tools on today’s problems – in a world, for example, that has become mu...

A healthy adult volunteers to serve as a control subject in an fMRI study. The subject provides informed consent, and a tailored protocol designed for the particular study then is executed. In most cases, the research subject altruistically assumes that the result will benefit science in some way. However, does science owe the volunteer a fair assessment of the information not relevant to the f...

In 2001, the National Highway Traffic Safety Administration (NHTSA) opened a public docket requesting comments from the public regarding headlamp glare. Most responses received have been complaints. NHTSA initiated research to address these complaints and to determine causes and effects of headlamp glare. In 2005, Congress authorized NHTSA to "conduct a study on the risks associated with glare ...

T comparative-effectiveness research (CER) movement has sparked an important debate about who may communicate research findings, for what purposes, and using what methodologic standards.1-3 CER is intended to inform discussions about what works in health care. Much of the information comes from research using retrospective databases and quasi-experimental designs rather than randomized clinical...

J MWardlaw professor of applied neuroimaging and honorary consultant neuroradiologist, H Davies research ethics adviser , T C Booth consultant neuroradiologist , G Laurie professor of medical jurisprudence, A Compston professor of neurology, C Freeman professor of psychiatry and clinical lead for accreditation , M O Leach professor of physics as applied to medicine , A D Waldman consultant neur...