OBJECTIVE To determine the factors associated with thyroid cancer, focusing on first-degree family history and ultrasonography (US) features, in euthyroid asymptomatic patients with thyroid nodules. MATERIALS AND METHODS This retrospective study included 1310 thyroid nodules of 1254 euthyroid asymptomatic patients who underwent US-guided fine-needle aspiration biopsy between November 2012 and...

IMPORTANCE Whole-genome sequencing (WGS) is increasingly applied in clinical medicine and is expected to uncover clinically significant findings regardless of sequencing indication. OBJECTIVES To examine coverage and concordance of clinically relevant genetic variation provided by WGS technologies; to quantitate inherited disease risk and pharmacogenomic findings in WGS data and resources req...

(a) The autopsy should be under the jurisdiction of the coroner, magistrate or other legal authority that authorises and request an autopsy. The very fact that there is the possibility of a non-natural cause of death makes the case reportable to the coroner. This is the duty of the clinicians, but sometimes they may not be very anxious to initiate a legal enquiry which may result in criticism, ...

BACKGROUND The majority of rare diseases are complex diseases caused by a combination of multiple morbigenous factors. However, uncovering the complex etiology and pathogenesis of rare diseases is difficult due to limited clinical resources and conventional statistical methods. This study aims to investigate the interrelationship and the effectiveness of potential factors of pediatric cataract,...

REPORTING INFORMATION  Class B2: Report by the end of the business week in which the case or suspected case presents and/or a positive laboratory result to the local public health department where the patient resides. If patient residence is unknown, report to the local public health department in which the reporting health care provider or laboratory is located.  Reporting Form(s) and/or Mec...

Coccidioidomycosis is a common cause of community-acquired pneumonia (CAP) in disease-endemic areas. Because testing rates influence interpretation of reportable-disease data and quality of CAP patient care, we determined the proportion of CAP patients who were tested for Coccidioides spp., identified testing predictors, and determined the proportion of tested patients who had positive coccidio...

This study explores relationships between current levels of information technology (IT) sophistication and seven reportable quality measures (QMs) in 210 nursing homes in Missouri. Between December 2006 and August 2007, each nursing home completed a survey providing IT sophistication levels measured within nine subscales. During this same time, nationally reported QMs were collected for each nu...