Thus far, several small studies and case reports on the use of topical immunomodulators in vitiligo have been published. We undertook a comprehensive literature review, searching for studies evaluating clinical response to tacrolimus topical therapy for vitiligo. A search was performed on PubMed/Medline using the term "vitiligo", combined with "topical" and "ointment". Our inclusion criteria we...

Vitiligo is an autoimmune skin disease that characterized by the progressive destruction of melanocytes autoreactive CD8+ T cells. Melanocyte in active vitiligo mediated cells but why white patches stable persist poorly understood. The interaction between immune cells, melanocytes, and keratinocytes situ human has been difficult to study due lack proper tools. We combine non-invasive multiphoto...

Vitiligo is a polygenic acquired skin disorder resulting from the destruction of melanocytes in epidermal cells. Conventional therapeutic options include covering agents, topical corticosteroids, immunomodulators, phototherapy with psolaren ultraviolet A (PUVA) and narrowband B (NBUVB). However, successful repigmentation these modalities expected only half patients. This study aimed to compare ...

A 4 year old female Labrador retriever was presented with a history of visual deficit for the past 3 months. A detailed ophthalmic examination with a direct and indirect ophthalmoscope revealed, sluggish PLR, shallow anterior chamber and irregular pupillary border and bilateral uveitis. There was progressive depigmentation of the retinal pigment epithelium in the nontapetal area, tapetal hyperr...

Abstract Plants are considered as a source of medicine to treat skin-related disorders since decades. Seeds Psoralea corylifolia were used thousands years ago for re-pigmentation in vitiligo patients especially South Asia. It is well-known fact that melanocytes, which the specialized cells skin causes through series chemical and enzymatic reactions, mainly due copper containing enzyme tyrosinas...

Vitiligo is an idiopathic skin depigmentation disorder with clinical symptoms of macules and depigmented patches on the skin. a multifactorial associated genetic non-genetic. There are two types vitiligo: non-segmental segmental vitiligo. The type vitiligo can be determined based physical examination affects disease course, prognosis, therapy response. management still challenge its own because...