We asked whether cyclooxygenase (COX) activity controls the renin-angiotensin system in the postnatal period. During kidney development, renin peaked at postnatal days 0-1 at the mRNA, tissue protein [renal renin concentration (RRC)], and plasma renin concentration (PRC) levels and was widely expressed along preglomerular vessels. PRC and renin mRNA expression was elevated until weaning in the ...

BACKGROUND In cirrhotic patients peripheral vasodilatation may decrease renal blood flow and subsequently raises plasma renin activity. Octreotide with several mechanisms causes peripheral arterial vasoconstriction. Midodrine is an alpha agonist and acts as a peripheral vasoconstrictor; therefore it may reduce plasma renin activity and improve renal function. In this study the effects of these ...

The vascular effects of aliskiren last longer than expected based on its half life, and this renin inhibitor has been reported to cause a greater renin rise than other renin-angiotensin system blockers. To investigate whether aliskiren accumulation in secretory granules contributes to these phenomena, renin-synthesizing mast cells were incubated with aliskiren, washed, and exposed to forskolin ...

Fifty years ago, investigators identified renin inhibition as the preferred pharmacologic approach to blockade of the renin-angiotensin system. Renin is a monospecific enzyme that catalyzes the rate-limiting step in the synthesis of angiotensin II. Amplified enzymatic activity and additional physiological effects occur when renin and pro-renin bind to the (pro)renin receptor. Until very recentl...

The effects of combined renin inhibition and converting enzyme inhibition on mean arterial pressure and the plasma renin-angiotensin system were studied in conscious rats. In sodium-replete rats the infusion of the renin inhibitor CP71362 (100 micrograms/kg/min) decreased blood pressure by 13 +/- 1 mm Hg (p less than 0.0001), reduced plasma renin activity to undetectable levels, but did not low...

Renin A from the submaxillary gland of male mice has been shown by a gas chromatography/mass spectrometry method to contain near stoichiometric amounts of a fatty acid mixture. The fatty acids on mouse renin were partially exchangeable with free tridecanoic acid in solution, with the tridecanoic acid truly exchanged and not just adsorbed in addition to the fatty acids already present. A gas chr...

Aortic renin-like activity and plasma renin concentration were measured in rats subjected to dietary salt loading or depletion. Homogenates prepared from rat aortic tissue generated angtotensin I from plasma substrate at both pH S3 and pH 6.5. Aortic renin-like activity measured at incubation pH 6.5 and plasma renin concentration changed in parallel, rising with salt restriction and falling wit...