Tubular cell apoptosis is involved in ischemic renal failure, but the underlying mechanism is unclear. Bid, a proapoptotic Bcl-2 family protein, may regulate the intrinsic as well as the extrinsic pathway of apoptosis. In vivo, Bid is most abundantly expressed in the kidneys. However, the role played by Bid in renal pathophysiology is unknown. Our recent work demonstrated Bid activation during ...

We previously demonstrated that there are acute and delayed phases of renal protection against renal ischemia and reperfusion (IR) injury with renal ischemic preconditioning (IPC). This study assessed whether hepatic IPC could also reduce distant renal IR injury through the blood stream-mediated supply of reactive oxygen species (ROS). Male C57BL/6 mice were randomly divided into four groups: g...

OBJECTIVE Ischemia/reperfusion (I/R) injury is a major cause of acute organ dysfunction and I/R related acute renal failure is a common clinical problem. Diabetes mellitus is defined as a risk factor for the development of acute renal injury as diabetic nephropathy compromises the renal tolerance to ischemia. The aim of this study was to investigate the protective effect of magnesium sulfate in...

Aldehyde dehydrogenase 2 (ALDH2) is an important factor in inhibiting oxidative stress and has been shown to protect against renal ischemia/reperfusion injury. Therefore, we hypothesized that ALDH2 could reduce spinal cord ischemia/reperfusion injury. Spinal cord ischemia/reperfusion injury was induced in rats using the modified Zivin's method of clamping the abdominal aorta. After successful m...

BACKGROUND In a prior study the 21-aminosteroid (lazaroid) U74389F provided in vivo protection from oxidative stress when used as a preventive therapy in ischemia-reperfusion injury in the kidney. As the cell membrane is the principal site for lipoperoxidation, in the current study the very lipophilic 2-methylaminochroman U83836E, a recently developed lazaroid, was administered to rats at 3 mg/...

ischemia-reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. ischemia-reperfusion brain injury initiates an inflammatory response involving the expression of adhesion molecules and cytokines. twenty–four male wistar rats (250-300 g body wt) were used in this study. the animals were divided into four groups of 6 rat...

Introduction: Liver ischemia/reperfusion (IR) is a major clinical problem, which occurs during several conditions such as liver damage, trauma and transplantation. Recent studies indicate that IR-induced acute liver failure causes injuries of distant organs such as heart and lungs by systematic inflammatory responses. Therefore, in the present study, effects of hepatic IR induction were studied...

OBJECTIVE This work aimed to investigate the effects of the administration of cannabidiol in a kidney ischemia/reperfusion animal model. METHODS Kidney injury was induced by 45 minutes of renal ischemia followed by reperfusion. Cannabidiol (5mg/kg) was administered immediately after reperfusion. RESULTS Ischemia/reperfusion increased the IL-1 and TNF levels, and these levels were attenuated...

Renal Ischemia/reperfusion injury (IRI) is characterized by the restriction of blood supply, followed restoration flow and re-oxygenation. Reperfusion itself paradoxically exacerbates tissue injury, threatening function, viability organ. IRI usually associated with a variety homeostatic changes that involve reduced energetics, oxidative processes contribute to mitochondrial dysfunction. Dependi...

Oxidative stress is a major contributor to kidney injury following ischemia reperfusion. Ferritin, a highly conserved iron-binding protein, is a key protein in the maintenance of cellular iron homeostasis and protection from oxidative stress. Ferritin mitigates oxidant stress by sequestering iron and preventing its participation in reactions that generate reactive oxygen species. Ferritin is co...