Release property of reservoir device matrix tablet was examined. Wax matrix layer was prepared from physical mixture of lactose and hydrogenated castor oil to obtain basic release properties. Release process showed zero order kinetics in a steady state after a given lag times, and could be divided into two stages. The first stage was the formation process of water channel by dissolving the solu...

Controlled release preparations have been reported to reduce the gastro irritant and ulcerogenic effects of non steroidal antiinflammatory drugs. In the present study, an attempt was made to develop matrix tablet-based controlled release formulations of ibuprofen, using ethyl cellulose as the rate-controlling polymer. In order to prevent initial release of the drug in the acidic environment of ...

the aim of the present study was to prepare and evaluate an osmotically controlled mucoadhesive cup-core (ocmc) containing aceclofenac. a special technique was used while preparing an ocmc. stability of ocmc was determined in natural human saliva, and it was found that both ph and device are stable in human saliva. ocmc was evaluated by weight uniformity, thickness, hardness, friability, swelli...