Like the biological clock in the body, replication of each cell type (even different cells of the same organism) follows a timing program. Abnormal function of this timer could be an alarm for a disease like cancer. DNA replication starts from a specific point on the chromosome that is called the origin of replication. In contrast to prokaryotes in which DNA replication starts from a single ...

Homogenous Charge Compression Ignition (HCCI) engines hold promise of high fuel efficiency and low emission levels for future green vehicles. But in contrast to gasoline and diesel engines, HCCI engines suffer from lack of having direct means to initiate combustion. A combustion timing controller with robust tracking performance is the key requirement to leverage HCCI application in production ...

Recent studies by Myors (1998, 1999) have concluded that the Microsoft Windows operating system is unable to support sufficient timing precision and resolution for use in psychological research. In the present study, we reexamined the timing accuracy of Windows 95/98, using (1) external chronometry, (2) methods to maximize the system priority of timing software, and (3) timing functions with a ...

Specifying and designing real-time systems is a complex matter because real-time systems require logical correctness as well as timing correctness. Over the years several techniques for specifying and designing real-time systems have been developed, such as Finite State Machines, Petri Nets and Timed CSP. One of the latest notations for object-oriented specification and design is the Unified Mo...

We propose market timing strategies aiming to exploit the aggregate accruals’ return forecasting power. We examine several performance metrics of the aggregate accruals based market timing strategy such as excess portfolio return, Sharpe ratio, and Jensen’s alpha. We provide robust evidence that, relative to the passive investment strategy of buying and holding the stock market, the market timi...

The timing and sequencing relationships of changes (events) in discrete sensors and actuators can be used to determine whether a manufacturing system is operating as expected. In this paper, we present a method of learning inter-event timing relationships using observations from a correctly operating system. The observed sample statistics characteristic of correct system operation are used to c...

In spike-timing-dependent plasticity (STDP), the order and precise temporal interval between presynaptic and postsynaptic spikes determine the sign and magnitude of long-term potentiation (LTP) or depression (LTD). STDP is widely utilized in models of circuit-level plasticity, development, and learning. However, spike timing is just one of several factors (including firing rate, synaptic cooper...

Although absolute variability in postnatal ossification timing is generaIly larger in boys than in girls, reIative, conception-corrected variability is signscantly larger in girls, suggestive of a “dosage” effect and consistent with the hypothesis of partial X-linkage. These findings, together with the excess of sister-sister over brother-brother timing similarities are inconsistent with the hy...