OBJECTIVE To evaluate the efficacy of amantadine in the treatment of symptoms and neurocognitive performance in adolescents following sports-related concussion. PARTICIPANTS A clinical sample of 25 male (n = 11) and female (n = 14) adolescent subjects with an age-, sex-, and concussion history-matched group of 25 male (n = 11) and female (n = 14) control subjects. SETTING Outpatient concuss...

After Zackery Lystedt’s brain injury, “he couldn’t speak for nine months,” his father said. Thirteen months later, “he could move his left arm a little; it took two years to get rid of the feeding tube and four years before he could move his right leg purposefully.” Zackery had suffered a concussion during a high school football game in 2006, but “was twice returned to play and collapsed 60 sec...

Sport-related concussion with its associated physical and cognitive symptoms has become an area of widespread interest with respect to developing techniques to best manage acute concussion effects, determining when concussed athletes may return to play without increased risk of further injury, as well as evaluating the long-term effects from repeated concussions sustained over many years and th...