Abstract Objective Definitive chemoradiotherapy (dCRT) is one of the standard treatments for esophageal squamous cell carcinoma (ESCC), but local recurrence main cause treatment failure. The changes in apoptosis and autophagy recurrent tumors patients with ESCC following dCRT have been poorly estimated. Thus, this study aimed to investigate expressions key regulators matched paired samples prim...

Objective(s): Oxidative stress has been established as a key cause of alcohol-induced hepatotoxicity. Licochalcone B, an extract of licorice root, has shown antioxidative properties. This study was to investigate the effects and mechanisms of licochalcone B in ethanol-induced hepatic injury in an in vitro study. Materials and Methods: An in vitro model of Ethanol-induced cytotoxicity in BRL cel...

The main role of cumulus cells (CC) is to provide nutritious materials for developing oocytes. Follicular fluid (FF) contains the enzyme acid phosphatase, which plays a role in ovulation and fertilization of oocyte. The objective of this prospective study was to evaluate the levels of acid phosphatase in FF and the rate of apoptosis in CC of fertilized and unfertilized oocytes in intracytoplasm...

Molecular farming has been considered as a secure and economical approach for production of biopharmaceuticals. Human TNF Related Apoptosis Inducing Ligand (TRAIL) as a promising biopharmaceutical candidate has been produced in different expression hosts. However, little attention has been paid to molecular farming of the TRAIL in spite of numerous advantages of plant expression systems. Theref...

Purpose: To examine the effect of nicorandil on high glucose-induced cardiomyocyte inflammation and oxidative stress.Methods: H9C2 cardiomyocytes were divided into control group, glucose group group. The survival rate was determined using CCK-8 method. contents reactive oxygen species (ROS) by flow cytometry. MDA LDH in cell supernatant kit. Western blot real-time PCR used to assess stress, apo...

Molecular farming has been considered as a secure and economical approach for production of biopharmaceuticals. Human TNF Related Apoptosis Inducing Ligand (TRAIL) as a promising biopharmaceutical candidate has been produced in different expression hosts. However, little attention has been paid to molecular farming of the TRAIL in spite of numerous advantages of plant expression systems. Theref...