In this study, we consider the problem of variable selection and estimation in high-dimensional linear regression models when complete data are not accessible, but only certain marginal information or summary statistics available. This is motivated from Genome-wide association studies (GWAS) that have been widely used to identify risk variants underlying complex human traits/diseases. With a la...

We propose a genetic association analysis using Dirichlet regression to analyze the Genetic Analysis Workshop 18 data. Clinical variables, arranged in a longitudinal data structure, are employed to fit a multistate transition model in which the transition probabilities are served as a response in the proposed analysis. Furthermore, a gene-based association analysis via penalized regression is i...

resistin (retn), recently found to be relevant to inflammation and inflammatory disorders. we, therefore, aimed to investigate the potential role of retn gene polymorphism in pathogenesis of acne vulgaris with familial history. we investigated the retn-420c/g polymorphism in 180 patients with acne vulgaris and 180 healthy individuals in a case-control association analysis. in this study, we als...

background: industrialization and urbanization had a devastating impact on public health and caused an increase in health related morbidity and mortality. in fact, asthma is a chronic condition which is considered as one of the significant challenges of public health. in this study, we investigated the association of air pollution and weather conditions with excess emergency ward admissions of ...

objective(s): to investigate the association of single nucleotide polymorphisms (snps) in the peroxisome proliferator-activated receptors gamma (pparg) with essential hypertension (eh) and additional role of gene– high-density lipoprotein cholesterol (hdl) interaction. materials and methods:a total of 1640 patients with eh (806 males, 834 females), with a mean age of 52.5±12.6 years, were selec...

background: association between the vitamin d deficiency and metabolic syndrome (mets) has previously been noted and reported to be controversial. the aim of this study was to determine the association of serum 25 (oh) d level and vitamin d dietary intake with mets among iranian population . methods: this analytical study was conducted on 122 patients with mets based on the atpiii criteria and ...

This paper explores the association between job strain and adiposity, using two statistical analysis approaches and considering the role of gender. The research evaluated 11,960 active baseline participants (2008-2010) in the ELSA-Brasil study. Job strain was evaluated through a demand-control questionnaire, while body mass index (BMI) and waist circumference (WC) were evaluated in continuous f...

©FSRH J Fam Plann Reprod Health Care 2008: 34(3) What is it? When a response variable has only two possible values (e.g. recurrence/not), binary logistic regression is commonly used to test or model the association between that response and a number of potential explanatory variables, with each association estimated in terms of an odds ratio (OR). Multinomial logistic regression is an extension...