INTRODUCTION: Repairing the damaged nervous system is one of the greatest challenges facing regenerative medicine. Research into nervous system repair can be separated into two broad areas covering the central nervous system (CNS) and the peripheral nervous system (PNS). Damage to peripheral nerves can lead to loss of sensation, motor function and muscle weakness, but the PNS is capable of sign...

UNLABELLED The identification of the molecular network that supports oligodendrocyte (OL) regeneration under demyelinating conditions has been a primary goal for regenerative medicine in demyelinating disorders. We recently described an essential function for TACE/ADAM17 in regulating oligodendrogenesis during postnatal myelination, but it is unknown whether this protein also plays a role in OL...

Regenerative medicine is an emerging field of biotechnology that combines various aspects of medicine, cell and molecular biology, materials science and bioengineering in order to regenerate, repair or replace tissues. The oral surgery and maxillofacial surgery have a role in the treatment of traumatic or degenerative diseases that lead to a tissue loss: frequently, to rehabilitate these minuse...

Background Liver disease contributes significantly to global disease burden and is associated with rising incidence and escalating costs. It is likely that innovative approaches, arising from the emerging field of liver regenerative medicine, will counter these trends. Main body Liver regenerative medicine is a rapidly expanding field based on a rich history of basic investigations into the n...

Tumor suppressors are so named because cancers occur in their absence, but these genes also have important functions in development, metabolism and tissue homeostasis. Here, we discuss known and potential functions of tumor suppressor genes during tissue regeneration, focusing on the evolutionarily conserved tumor suppressors pRb1, p53, Pten and Hippo. We propose that their activity is essentia...

In spite of tremendous strides in modern medicine there has been no drug that stimulates the function of the liver, protects it from damage or helps in the regeneration of hepatic cells. Liv.52 is reported to be a powerful hepatic stimulant and choleretic which increases the functional capacity of the liver and accelerates cellular metabolic activity and promotes regeneration and shows marked l...

Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/peri...

Contrary to many other illness, for patients with end-stage organ failure there is a lifesaving yet inaccessible cure—transplant. The median survival time of adult recipients can be three fourfold longer as compared on the waiting list.1 Despite success transplantation, 730 000 annual deaths attributable disease in United States, less than 40 receive an because serious donor shortage crisis.2, ...